Evidence map›Paper›PMID 33661978›Full record

ArticlePloS one2021

Ten-year cardiovascular risk among cancer survivors: The National Health and Nutrition Examination Survey.

Xiaochen Zhang, Meghan Pawlikowski, Susan Olivo-Marston, Karen Patricia Williams, Julie K Bower, Ashley S Felix

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

  1. Increasing physical activity in Cancer Survivors through a Text-messaging Exercise motivation Program (ICanSTEP).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Trial
  2. Review
  3. Research Priorities and Future Directions in Cardio-Oncology.Current treatment options in oncology · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Residual Traditional Risk in Non-Traditional Atherosclerotic Diseases.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaochen ZhangDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio, United States of America.ORCID 0000-0003-3086-1285
Meghan PawlikowskiDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio, United States of America.
Susan Olivo-MarstonDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio, United States of America.
Karen Patricia WilliamsMartha S. Pitzer Center for Women, Children, and Youth, College of Nursing, The Ohio State University, Columbus, Ohio, United States of America.
Julie K BowerDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio, United States of America.
Ashley S FelixDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio, United States of America.
The Ohio State University · US

Funding

Effect of adiposity changes on endometrial tissue and blood biomarkers in women at increased risk for endometrial cancerK01CA218457 · NCI · OHIO STATE UNIVERSITY · PI FELIX, ASHLEY S. · 2018 to 2022
$703k
Addressing Obesity to Reduce Cancer Risk and Health Disparities in Underserved PopulationsF99CA253745 · NCI · OHIO STATE UNIVERSITY · PI ZHANG, XIAOCHEN · 2020 to 2021
$86k
NCI NIH HHS F99 CA253745NCI NIH HHS K01 CA218457
6 · The paper itself

Abstract

backgroundCancer survivors have a higher risk of developing and dying from cardiovascular disease (CVD) compared to the general population. We sought to determine whether 10-year risk of atherosclerotic CVD (ASCVD) is elevated among those with vs. without a cancer history in a nationally representative U.S. sample.

methodsParticipants aged 40-79 years with no CVD history were included from the 2007-2016 National Health and Nutrition Examination Survey. Cancer history was self-reported and 10-year risk of ASCVD was estimated using Pooled Cohort Equations. We used logistic regression to estimate associations between cancer history and odds of elevated (≥7.5%) vs. low (<7.5%) 10-year ASCVD risk. An interaction between age and cancer history was examined.

resultsA total of 15,095 participants were included (mean age = 55.2 years) with 12.3% (n = 1,604) reporting a cancer history. Individuals with vs. without a cancer history had increased odds of elevated 10-year ASCVD risk (OR = 3.42, 95% CI: 2.51-4.66). Specifically, those with bladder/kidney, prostate, colorectal, lung, melanoma, or testicular cancer had a 2.72-10.47 higher odds of elevated 10-year ASCVD risk. Additionally, age was an effect modifier: a cancer history was associated with 1.24 (95% CI: 1.19-4.21) times higher odds of elevated 10-year ASCVD risk among those aged 60-69, but not with other age groups.

conclusionsAdults with a history of self-reported cancer had higher 10-year ASCVD risk. ASCVD risk assessment and clinical surveillance of cardiovascular health following a cancer diagnosis could potentially reduce disease burden and prolong survival, especially for patients with specific cancers and high ASCVD risk.

Indexed as

AdultAgedCancer SurvivorsCardiovascular DiseasesFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedNeoplasmsSelf ReportSurveys and Questionnaires

Identifiers

PMID33661978
PMCPMC7932508
OpenAlexW3135646559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.