Evidence map›Paper›PMID 33661576›Full record

ArticleCurrent protocols2021

Cardio Phenotypic Potential of Mesenchymal Stem Cells.

Karen M Peterson, Federico Franchi, M Olthoff, Ramasamy Paulmurugan, Martin Rodriguez-Porcel

Erratum issuedAbstract read
In one paragraph

Article in Current protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mesenchymal stromal cells forFrontiers in microbiology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Karen M PetersonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Federico FranchiDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
M OlthoffDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Ramasamy PaulmuruganDepartment of Radiology, Stanford University School of Medicine, Stanford, California.
Martin Rodriguez-PorcelDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.

Funding

Imaging mitochondrial function of progenitor cells transplanted to the ischemic myocardiumR01HL119795 · NHLBI · MAYO CLINIC ROCHESTER · PI RODRIGUEZ-PORCEL, MARTIN · 2016 to 2020
$3.1M
Therapeutic miRNA Modulation of Hepatocellular Carcinoma Using Ultrasound Guided Drug DeliveryR01CA209888 · NCI · STANFORD UNIVERSITY · PI DAHL, JEREMY, PAULMURUGAN, RAMASAMY · 2017 to 2021
$3.1M
Non-invasive imaging of progenitor cell fate in the ischemic myocardiumR56HL113371 · NHLBI · MAYO CLINIC ROCHESTER · PI RODRIGUEZ-PORCEL, MARTIN · 2013 to 2013
$533k
NCI NIH HHS R01 CA209888NHLBI NIH HHS R01 HL119795NHLBI NIH HHS R56 HL113371
6 · The paper itself

Abstract

Cell therapy is being investigated as a powerful intervention to ameliorate the consequences of coronary artery disease. Among the different stem cell options, mesenchymal stem cells (MSCs) are particularly attractive due to their high availability, as well as immune-privileged status. However, it is still unclear whether mesenchymal stem cells can acquire cardiomyogenic characteristics after they are transplanted to the myocardium. In this article, we outline protocols that illustrate the plasticity of MSCs and their ability to acquire cardiogenic characteristics when they are in an ischemic-like environment, as typically encountered after transplantation into the ischemic heart. © 2021 Wiley Periodicals LLC. Basic Protocol 1: Isolation of mesenchymal stem cells (MSCs) Support Protocol 1: Characterization of MSCs by flow cytometry Basic Protocol 2: Isolation of neonatal cardiomyoctes (NCMs) Support Protocol 2: Characterization of NCMs Basic Protocol 3: Cardiogenic plasticity of MSCs under ischemic-like conditions Support Protocol 3: Characterization of the cardiomyogenic potential of MSCs.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationMyocardial InfarctionHumansMyocardiumMyocytes, Cardiaccardiogenicluciferasemesenchymal stem cellsneonatal cardiomyocytes

Identifiers

PMID33661576
PMCPMC11494489

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.