ArticleCerebellum (London, England)2021
Functional Convergence of Motor and Social Processes in Lobule IV/V of the Mouse Cerebellum.
Article in Cerebellum (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Striatal social reward sensitivity predicts trust-related brain responses depending on closeness and depression.Biological psychology · 2026Article
- Lobular and Voxel-Wise Genetic Influences on Cerebellar Gray Matter Volume and Associations With Social and Trait Anxiety in Twins.Human brain mapping · 2026Article
- Neuroplasticity in Spinal Circuits Mediated by Sexual Experience and Cerebellar Lobules.NeuroSci · 2026Article
- Cerebellar structure and function abnormalities in 16p11.2 microduplication mice.Brain communications · 2026Article
- Voluntary running reduces loss of PTEN-deficient Purkinje cells, modulates their metabolic signaling, and improves motor deficits in mice.Frontiers in cellular neuroscience · 2026Article
- Bridging cognitive reserve and cerebellar networks: counteracting brain damage in patients with Alzheimer's disease at different clinical stages.Frontiers in cellular neuroscience · 2026Article
- A Del(5PNAS nexus · 2025Article
- Central nervous system control of breathing in natural conversation turn-taking.Scientific reports · 2025Article
- PTEN deficiency in postnatally developing Purkinje cells disrupts metabolic signaling, leading to dendritic abnormalities and sex-specific behavioral deficits.Scientific reports · 2025Article
- Article
- Serotonergic Input into the Cerebellar Cortex Modulates Anxiety-Like Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Individualized cerebellar damage predicts the presence of behavioral disorders in children with brainstem tumors.Communications medicine · 2025Article
- Network localization of altered auditory and somatosensory sensitivity based on causal brain lesions.Brain communications · 2025Article
- Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG.Nature communications · 2024Article
- Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (bioRxiv : the preprint server for biology · 2024Article
- Nasal obstruction during development leads to defective synapse elimination, hypersynchrony, and impaired cerebellar function.Communications biology · 2024Article
- Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice.Cerebellum (London, England) · 2024Review
- The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology.Frontiers in pharmacology · 2024Article
- Hindbrain Stimulation Modulates Object Recognition Discrimination Efficiency and Hippocampal Synaptic Connections.Brain sciences · 2023Article
- Social memory deficit caused by dysregulation of the cerebellar vermis.Nature communications · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Topographic organization of the cerebellum is largely segregated into the anterior and posterior lobes that represent its "motor" and "non-motor" functions, respectively. Although patients with damage to the anterior cerebellum often exhibit motor deficits, it remains unclear whether and how such an injury affects cognitive and social behaviors. To address this, we perturbed the activity of major anterior lobule IV/V in mice by either neurotoxic lesion or chemogenetic excitation of Purkinje cells in the cerebellar cortex. We found that both of the manipulations impaired motor coordination, but not general locomotion or anxiety-related behavior. The lesioned animals showed memory deficits in object recognition and social-associative recognition tests, which were confounded by a lack of exploration. Chemogenetic excitation of Purkinje cells disrupted the animals' social approach in a less-preferred context and social memory, without affecting their overall exploration and object-based memory. In a free social interaction test, the two groups exhibited less interaction with a stranger conspecific. Subsequent c-Fos imaging indicated that decreased neuronal activities in the medial prefrontal cortex, hippocampal dentate gyrus, parahippocampal cortices, and basolateral amygdala, as well as disorganized modular structures of the brain networks might underlie the reduced social interaction. These findings suggest that the anterior cerebellum plays an intricate role in processing motor, cognitive, and social functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.