Evidence map›Paper›PMID 33661457›Full record

ArticleJournal of neurovirology2021

Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31.

Jonathan E Fogle, Lola Hudson, Andrea Thomson, Barbara Sherman, Margaret Gruen, B Duncan Lacelles, Brenda M Colby, Gillian Clary, Frank Longo, Rick B Meeker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jonathan E FogleDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607, USA.
Lola HudsonDepartment of Molecular and Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607, USA.
Andrea ThomsonDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607, USA.
Barbara ShermanDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607, USA.
Margaret GruenDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607, USA.
B Duncan LacellesDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607, USA.
Brenda M ColbyDepartment of Molecular and Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607, USA.
Gillian ClarySyneos Health, Morrisville, NC, 27560, USA.
Frank LongoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, NC, 94305, USA.
Rick B MeekerDepartment of Neurology and Neurobiology Curriculum, University of North Carolina, Chapel Hill, NC, 27599, USA. meekerr@neurology.unc.edu.ORCID http://orcid.org/0000-0002-7487-5315
North Carolina State University · USStanford University · USSyneos Health (United States) · USUniversity of North Carolina at Chapel Hill · US

Funding

Microglia and choroid plexus macrophages in Neuro-AIDSR01MH063646 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEEKER, RICK B · 2002 to 2009
$2.0M
Neurotrophin mimetic therapeutics for HIV-associated neural dysfunctionR01MH085606 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEEKER, RICK B · 2009 to 2013
$1.7M
LM11A-31 neuroprotective efficacy in an animal model of HIVR21NS086426 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEEKER, RICK B · 2014 to 2015
$771k
Quantifying cognitive-motor decline in FIV-infected catsR21NS066843 · NINDS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HUDSON, LOLA C · 2009 to 2010
$414k
NIMH NIH HHS R01 MH063646NIMH NIH HHS R01 MH085606NINDS NIH HHS R21 NS066843NINDS NIH HHS R21 NS086426
6 · The paper itself

Abstract

HIV rapidly infects the central nervous system (CNS) and establishes a persistent viral reservoir within microglia, perivascular macrophages and astrocytes. Inefficient control of CNS viral replication by antiretroviral therapy results in chronic inflammation and progressive cognitive decline in up to 50% of infected individuals with no effective treatment options. Neurotrophin based therapies have excellent potential to stabilize and repair the nervous system. A novel non-peptide ligand, LM11A-31, that targets the p75 neurotrophin receptor (p75

Indexed as

AnimalsCatsCognition DisordersFeline Acquired Immunodeficiency SyndromeImmunodeficiency Virus, FelineIsoleucineMorpholinesNeuroprotective AgentsReceptor, Nerve Growth FactorIsoleucineLM11A-31MorpholinesNeuroprotective AgentsReceptor, Nerve Growth FactorBehaviorHuman immunodeficiency virusNeurocognitiveNeuroprotectionNeurotrophin,Therapy

Identifiers

PMID33661457
PMCPMC9210987
OpenAlexW3135173274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.