ArticleeLife2021
NMDA receptors control development of somatosensory callosal axonal projections.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- The Molecular Machinery of Synaptic Plasticity and Its Potential Role in the Aetiology of Schizophrenia.Molecular neurobiology · 2026Review
- Molecular continuity between axon guidance and synaptic function.Molecules and cells · 2026Review
- Bilateral integration in somatosensory cortex is controlled by behavioral relevance.Nature neuroscience · 2025Article
- Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Bridging the gap: insights into sensorimotor deficits in NMDA receptor antibody encephalitis.The Journal of clinical investigation · 2025Article
- PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors.Nature neuroscience · 2025Article
- Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain.Trends in neurosciences · 2024Review
- Very Long-Term Functional Outcomes and Dependency in Children With Anti-NMDA Receptor Encephalitis.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Callosal inputs generate side-invariant receptive fields in the barrel cortex.Science advances · 2023Article
- The effects of the NMDAR co-agonist D-serine on the structure and function of optic tectal neurons in the developing visual system.Scientific reports · 2023Article
- Molecular mechanisms of corpus callosum development: a four-step journey.Frontiers in neuroanatomy · 2023Review
- The functional characterization of callosal connections.Progress in neurobiology · 2022Review
- Postnatal Development of Centrifugal Inputs to the Olfactory Bulb.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Callosal projections from primary somatosensory cortex (S1) are key for processing somatosensory inputs and integrating sensory-motor information. How the callosal innervation pattern in S1 is formed during early postnatal development is not clear. We found that the normal termination pattern of these callosal projections is disrupted in cortex specific NMDAR mutants. Rather than projecting selectively to the primary/secondary somatosensory cortex (S1/S2) border, axons were uniformly distributed throughout S1. In addition, the density of this projection increased over postnatal life until the mice died by P30. By combining genetic and antibody-mediated loss of function, we demonstrated that it is GluN2B-containing NMDA receptors in target S1 that mediate this guidance phenotype, thus playing a central role in interhemispheric connectivity. Furthermore, we found that this function of NMDA receptors in callosal circuit formation is independent of ion channel function and works with the EPHRIN-B/EPHB system. Thus, NMDAR in target S1 cortex regulates the formation callosal circuits perhaps by modulating EPH-dependent repulsion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.