ArticleJournal of the American Chemical Society2021
Photochemical C-H Activation Enables Nickel-Catalyzed Olefin Dicarbofunctionalization.
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed.
- Photocatalytic multicomponent alkene dicarbofunctionalizationChemical science · 2026Article
- Nickel-Catalyzed Twofold Conjunctive Coupling via Philicity-Alternating Radical Relay.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multireference Modeling Reveals the Origins of L‑Edge X‑ray Absorption Features in Photoredox-Active Nickel Complexes.The journal of physical chemistry. C, Nanomaterials and interfaces · 2026Article
- A Unified Synthetic Approach to 2-Alkyl Azetidines, Oxetanes, Thietanes and Cyclobutanes from Unactivated Alkenes.Journal of the American Chemical Society · 2025Article
- Photochemical Synthesis of Ynones from Aryl Aldehydes and Sulfone-Based Alkynes.The Journal of organic chemistry · 2025Article
- A Sustainable-by-Design Process for the Selective Photooxidation of Ethylbenzene in a Scalable Agitated Baffle Reactor.ACS omega · 2025Article
- COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nickel-Mediated Radical Capture: Evidence for a Concerted Inner-Sphere Mechanism.Journal of the American Chemical Society · 2025Article
- Organic photoredox-catalyzed unimolecular PCET of benzylic alcohols.Chemical science · 2025Article
- C1-4 Alkylation of Aryl Bromides with Light Alkanes enabled by Metallaphotocatalysis in Flow.Angewandte Chemie (International ed. in English) · 2025Article
- The current utility and future potential of multiborylated alkanes.Nature reviews. Chemistry · 2024Review
- Asymmetric paired oxidative and reductive catalysis enables enantioselective alkylarylation of olefins with C(spNature communications · 2024Article
- Synergistic Merger of Ketone, Halogen Atom Transfer (XAT), and Nickel-Mediated C(spACS organic & inorganic Au · 2024Article
- Synthesis of Indolyl Phenyl Diketones through Visible-Light-Promoted Ni-Catalyzed Intramolecular Cyclization/Oxidation Sequence of Ynones.ACS organic & inorganic Au · 2024Article
- Nickel-catalysed enantioselective alkene dicarbofunctionalization enabled by photochemical aliphatic C-H bond activation.Nature catalysis · 2024Article
- Chemoselective bond activation by unidirectional and asynchronous PCET using ketone photoredox catalysts.Chemical science · 2023Article
- Selective C(spNature communications · 2023Article
- Recent Advances in C-H Functionalisation through Indirect Hydrogen Atom Transfer.Molecules (Basel, Switzerland) · 2023Review
- Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes.Journal of the American Chemical Society · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
Alkenes, ethers, and alcohols account for a significant percentage of bulk reagents available to the chemistry community. The petrochemical, pharmaceutical, and agrochemical industries each consume gigagrams of these materials as fuels and solvents each year. However, the utilization of such materials as building blocks for the construction of complex small molecules is limited by the necessity of prefunctionalization to achieve chemoselective reactivity. Herein, we report the implementation of efficient, sustainable, diaryl ketone hydrogen-atom transfer (HAT) catalysis to activate native C-H bonds for multicomponent dicarbofunctionalization of alkenes. The ability to forge new carbon-carbon bonds between reagents typically viewed as commodity solvents provides a new, more atom-economic outlook for organic synthesis. Through detailed experimental and computational investigation, the critical effect of hydrogen bonding on the reactivity of this transformation was uncovered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.