ArticleCroatian medical journal2021
Association of the imaging characteristics of desmoplasia on digital breast tomosynthesis and the Ki-67 proliferation index in invasive breast cancer.
Article in Croatian medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 5 citations in OpenAlex.
- Spatial Configurations of 3D Extracellular Matrix Collagen Density and Anisotropy Simultaneously Guide Angiogenesis.PLoS computational biology · 2023Article
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2 authors at 1 institution in 1 country.
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Abstract
aimTo evaluate the imaging characteristics of desmoplasia on digital breast tomosynthesis (DBT) and their association with the Ki-67 index.
methodsSeventy-seven malignant spiculated breast masses were analyzed in terms of tumor size, length and width of spicules, coverage of tumor margin with spicules, and the number of spicules. The Ki-67 index was obtained from surgically removed tumor specimens.
resultsThe average spicule length was significantly negatively associated with a high Ki-67 (P=0.005, odds ratio [OR] 0.252, 95% confidence interval [CI] 0.094-0.676), ie, the lesions with longer spicules had a 3.968 times lower odds of having a high Ki-67 than the lesions with shorter spicules. The average spicule width at the base was significantly positively associated with Ki-67 (P=0.004, OR 3.939, 95% CI 1.520-10.209), ie, the lesions with thick spicules had a 3.939 times higher odds of having a high Ki-67 than the lesions with thin spicules. The lesions with more than 20 spicules and those with partially spiculated margins more frequently had a high Ki-67 than those with fewer spicules and fully spiculated margins, but the differences were not significant.
conclusionThe spiculation analysis could be used as a non-invasive method providing information about malignant lesions. The tumor proliferative activity, and therefore the patient's prognosis, might be predicted before biopsy directly from DBT images.
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33660962PMC7976888W3133522612What OpenQuestion holds
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