ArticleJournal of diabetes investigation2021
Association between influenza and the incidence rate of new-onset type 1 diabetes in Japan.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Comparison of Influenza Epidemic Trends Based on a Large-scale Claims Database and National Infectious Disease Surveillance in Japan.Journal of epidemiology · 2026Article
- Incidence of diabetes mellitus following hospitalisation with influenza: a population-based cohort study in England.BMJ open · 2026Article
- Article
- Multiple or Single Endocrine Abnormalities Associated With Immune Checkpoint Inhibitors.The Journal of clinical endocrinology and metabolism · 2025Article
- Immune checkpoint inhibitor-related type 1 diabetes incidence, risk, and survival association.Journal of diabetes investigation · 2025Article
- Article
- Case report: Takotsubo cardiomyopathy and cardiac arrest in a 9-year-old girl with new-onset diabetes presenting with diabetic ketoacidosis: the chicken or the egg?Frontiers in endocrinology · 2025Article
- The intersection of influenza infection and autoimmunity.Frontiers in immunology · 2025Review
- Seasonal Variation in Type 1 Diabetes Incidence in Poland: Exploring the Impact of Viral Infections, Including COVID-19.Pediatric diabetes · 2025Article
- Literature Review of Studies Using the National Database of the Health Insurance Claims of Japan (NDB): Limitations and Strategies in Using the NDB for Research.JMA journal · 2024Review
- Incidence of Diabetes Among Youth Before and During the COVID-19 Pandemic.JAMA network open · 2023Article
- Does COVID-19 Infection Increase the Risk of Diabetes? Current Evidence.Current diabetes reports · 2023Review
- Fulminant type 1 diabetes developed after influenza split vaccination.Endocrinology, diabetes & metabolism case reports · 2023Article
- Seasonal Influenza Vaccination among Patients with Comorbidities in the Countries of the GCC: A Responsibility or an Option?Oman medical journal · 2023Article
- Respiratory infections and type 1 diabetes: Potential roles in pathogenesis.Reviews in medical virology · 2023Review
- Are Viral Infections Key Inducers of Autoimmune Diseases? Focus on Epstein-Barr Virus.Viruses · 2022Review
- Association between influenza and the incidence rate of new-onset type 1 diabetes in Japan.Journal of diabetes investigation · 2021Article
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Authors and funding
10 authors.
Funding
Abstract
aimThis study aimed to determine whether there is an association between influenza and new-onset type 1 diabetes. MATERIALS AND
methodsThis population-based retrospective cohort study used data from the National Database of Health Insurance Claims and Specific Health Check-ups of Japan. Influenza was defined based on drug prescriptions and the onset of type 1 diabetes was defined using specific medical codes indicating a diagnosis of type 1 diabetes. The incidence rate ratio of new-onset type 1 diabetes within 180 days after an influenza diagnosis was calculated and it was compared with that at other times using Poisson regression and generalized estimating equations. Sensitivity analyses were performed to confirm the robustness of this finding.
resultsThe data of 10,400 patients with new-onset type 1 diabetes were analyzed, including 2,196 (952 male 1,244 female) patients diagnosed with influenza between 1 September 2014 and 31 August 2017. Although only patients with type 1 diabetes were included, adjusted analysis showed that individuals had a 1.3-fold (95% confidence interval: 1.15-1.46) higher risk of developing type 1 diabetes in the first 180 days after influenza diagnosis than that at other times.
conclusionsIn this Japanese population-based cohort, the risk of new-onset type 1 diabetes may increase after the diagnosis of influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new-onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated.
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