Evidence map›Paper›PMID 33660622›Full record

ArticleJournal of the Chinese Medical Association : JCMA2021

Differences in intestinal microbiota profiling after upper and lower gastrointestinal surgery.

Xi-Hsuan Lin, Ueng-Cheng Yang, Jiing-Chyuan Luo, Tien-En Chang, Hung-Hsin Lin, Chi-Wei Huang, Jen-Jie Chiou, Wen-Liang Fang, Kuo-Hung Huang, Yi-Hsiang Huang and 2 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Chinese Medical Association : JCMA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Xi-Hsuan LinDepartment of Medicine, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan, ROC.
Ueng-Cheng YangSchool of Medicine, Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Jiing-Chyuan LuoDepartment of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.
Tien-En ChangDepartment of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.
Hung-Hsin LinDepartment of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.
Chi-Wei HuangSchool of Medicine, Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Jen-Jie ChiouSchool of Medicine, Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Wen-Liang FangDepartment of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.
Kuo-Hung HuangDepartment of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.
Yi-Hsiang HuangDepartment of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.
Ming-Chih HouDepartment of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.
Fa-Yauh LeeDepartment of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to investigate the long-term effects of metabolic profiles and microbiota status in patients after upper gastrointestinal (GI) surgery and lower GI surgery and compared them with a control group.

methodsIn this cross-sectional study, we analyzed the occurrence of metabolic syndrome (MS) in 10 patients who underwent curative total gastrectomy with Roux-en-Y esophagojejunostomy (RYEJ) anastomosis, 11 patients who underwent curative partial colectomy with right hemicolectomy (RH), and 33 age- and sex-matched controls. Fecal samples were also analyzed by a next-generation sequencing method.

resultsCompared with the control group, the occurrence of MS was significantly lower among patients who underwent total gastrectomy with RYEJ than the controls over the long-term follow-up (>8 years; p < 0.05). Patients who received RH only had a trend of higher serum fasting glucose (p = 0.10). The diversity of the gut microbiota significantly decreased after RH in comparison with the control group and RYEJ group, respectively (p < 0.05). Principal component analysis revealed significant differences between the control, RYEJ, and RH groups (p < 0.001). At the genus level, the ratio of Prevotella to Bacteroides (P/B) was significantly higher in the RYEJ group than in the control group, whereas the P/B ratio was significantly lower in the RH group than in the control group (p < 0.05).

conclusionEarly gastric cancer patients who received total gastrectomy with RYEJ had a lower occurrence of MS than the controls, while early colorectal cancer patients who received RH were associated with a higher serum fasting glucose than the controls during long-term follow-up. In parallel with the metabolic differences, the P/B ratio was also significantly altered in patients after upper and lower GI surgery.

Indexed as

Gastrointestinal MicrobiomeAgedColectomyCross-Sectional StudiesFemaleHumansMaleMiddle AgedPolymerase Chain ReactionPostoperative PeriodStomach Neoplasms

Identifiers

PMID33660622
PMCPMC12966043
OpenAlexW3134223201

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.