Evidence map›Paper›PMID 33660532›Full record

SynthesisJournal of the American Heart Association2021

Discontinuity of Cardiac Follow-Up in Young People With Congenital Heart Disease Transitioning to Adulthood: A Systematic Review and Meta-Analysis.

Philip Moons, Sandra Skogby, Ewa-Lena Bratt, Liesl Zühlke, Ariane Marelli, Eva Goossens

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  9. Point of care INR monitoring in cyanotic congenital heart disease-related compensatory erythrocytosis.International journal of cardiology. Congenital heart disease · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Philip MoonsDepartment of Public Health and Primary Care KU Leuven Belgium.
Sandra SkogbyDepartment of Public Health and Primary Care KU Leuven Belgium.
Ewa-Lena BrattInstitute of Health and Care SciencesUniversity of Gothenburg Sweden.
Liesl ZühlkeDepartment of Pediatrics and Child Health University of Cape Town South Africa.
Ariane MarelliMcGill Adult Unit for Congenital Heart Disease Excellence (MAUDE Unit) McGill University Health Center Montreal QC Canada.
Eva GoossensDepartment of Public Health and Primary Care KU Leuven Belgium.

Funding

Medical Research Council MR/S005242/1
6 · The paper itself

Abstract

Background The majority of people born with congenital heart disease require lifelong cardiac follow-up. However, discontinuity of care is a recognized problem and appears to increase around the transition to adulthood. We performed a systematic review and meta-analysis to estimate the proportion of adolescents and emerging adults with congenital heart disease discontinuing cardiac follow-up. In pooled data, we investigated regional differences, disparities by disease complexity, and the impact of transition programs on the discontinuity of care. Methods and Results Searches were performed in PubMed, Embase, Cinahl, and Web of Science. We identified 17 studies, which enrolled 6847 patients. A random effects meta-analysis of single proportions was performed according to the DerSimonian-Laird method. Moderator effects were computed to explore sources for heterogeneity. Discontinuity proportions ranged from 3.6% to 62.7%, with a pooled estimated proportion of 26.1% (95% CI, 19.2%-34.6%). A trend toward more discontinuity was observed in simple heart defects (33.7%; 95% CI, 15.6%-58.3%), compared with moderate (25.7%; 95% CI, 15.2%-40.1%) or complex congenital heart disease (22.3%; 95% CI, 16.5%-29.4%) (

Indexed as

AdolescentAdultFollow-Up StudiesGlobal HealthHeart Defects, CongenitalHumansMorbidityTransitional Carecare gapscontinuity of careheart defects, congenitallapse of carelost to follow‐upmeta‐analysissystematic review

Identifiers

PMID33660532
PMCPMC8174191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.