Evidence map›Paper›PMID 33660232›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2021

Associations Between Endometriosis and Gut Microbiota.

Agnes Svensson, Louise Brunkwall, Bodil Roth, Marju Orho-Melander, Bodil Ohlsson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 139 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Agnes SvenssonDepartment of Internal Medicine, Skåne University Hospital, Lund University, Jan Waldenströms street 15, floor 5, 20502, Malmö, Sweden.
Louise BrunkwallDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
Bodil RothDepartment of Internal Medicine, Skåne University Hospital, Lund University, Jan Waldenströms street 15, floor 5, 20502, Malmö, Sweden.
Marju Orho-MelanderDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
Bodil OhlssonDepartment of Internal Medicine, Skåne University Hospital, Lund University, Jan Waldenströms street 15, floor 5, 20502, Malmö, Sweden. Bodil.ohlsson@med.lu.se.ORCID 0000-0002-9142-5244
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota has been associated with many diseases, including endometriosis. However, very few studies have been conducted on this topic in human. This study aimed to investigate the association between endometriosis and gut microbiota. Women with endometriosis (N=66) were identified at the Department of Gynaecology and each patient was matched with three controls (N=198) from the general population. All participants answered questionnaires about socioeconomic data, medical history, and gastrointestinal symptoms and passed stool samples. Gut bacteria were analyzed using 16S ribosomal RNA sequencing, and in total, 58 bacteria were observed at genus level in both patients with endometriosis and controls. Comparisons of the microbiota between patients and controls and within the endometriosis cohort were performed. Both alpha and beta diversities were higher in controls than in patients. With the false discovery rate q<0.05, abundance of 12 bacteria belonging to the classes Bacilli, Bacteroidia, Clostridia, Coriobacteriia, and Gammaproteobacter differed significantly between patients and controls. Differences observed between patients with or without isolated ovarian endometriosis, involvement of the gastrointestinal tract, gastrointestinal symptoms, or hormonal treatment disappeared after calculation with false discovery rate. These findings indicate that the gut microbiota may be altered in endometriosis patients.

Indexed as

AdultBacteriaEndometriosisFecesFemaleGastrointestinal MicrobiomeHumansRNA, Ribosomal, 16SSurveys and QuestionnairesRNA, Ribosomal, 16SEndometriosisGastrointestinal symptomsGut microbiotaPathophysiology

Identifiers

PMID33660232
PMCPMC8289757
OpenAlexW3133497097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.