ArticleJournal of gastrointestinal cancer2022
In Vitro Cytotoxicity and Apoptotic Assay of Eucalyptus globulus Essential Oil in Colon and Liver Cancer Cell Lines.
Article in Journal of gastrointestinal cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Review
- Nanoemulsions of 1,8-cineole, and Eucalyptus globulus and Laurus nobilis essential oils: cytotoxic, antibacterial, and antioxidant activities.BMC complementary medicine and therapies · 2026Article
- GC/MS Analysis, Cytotoxicity, and Antimicrobial Properties of Six Moroccan Essential Oils Traditionally Used for COVID-19 Prevention.Molecules (Basel, Switzerland) · 2025Article
- In vitro bioactivities and formulation stability of Houttuynia cordata essential oil for cosmetic applications.Scientific reports · 2025Article
- Deciphering the Mechanisms Underlying the Antitumor Effects of Eucalyptus Essential Oil and Its Component 3-Cyclohexene-1-Methanol Against Human Colon Cancer Cells.International journal of molecular sciences · 2025Article
- Chemical Characterization, Sensory Evaluation, and Biological Activity in Neuronal Cells of Essential Oils (Rose, Eucalyptus, Lemon, and Clove) Used for Olfactory Training.Molecules (Basel, Switzerland) · 2025Article
- Eucalyptus Essential Oil Inhibits Cell Infection by SARS-CoV-2 Spike Pseudotyped Lentivirus.Biomedicines · 2024Article
- Enhancing prediction accuracy of foliar essential oil content, growth, and stem quality inFrontiers in plant science · 2024Article
- Review
- A Fresh Look at Mouthwashes-What Is Inside and What Is It For?International journal of environmental research and public health · 2022Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeToxic effects of vegetables have been the subject of numerous investigations in recent years. Eucalyptus globulus of the Myrtaceae family has been traditionally used in the treatment of various infectious disorders. This study aims to assay the potential anticancer effect of Eucalyptus globulus essential oil, in vitro, and compare its cytotoxic effects on cancerous and non-cancerous cell lines.
methodsThe cytotoxicity of the Eucalyptus globulus essential oil was evaluated in colon cancer cell line SW48, liver cancer cell line HepG2, HEK293t, and skin fibroblast using the MTT assay. We used 5-FU as the control treatment for cancer. The essential oil was diluted by phosphate buffer saline in cell culture.
resultsEucalyptus globulus essential oil with the concentration of 0.01% did not reduce the cell viability of SW48 (IC50 = 0.2%) and fibroblast cells (IC50 = 5%) after a 48-h treatment period. Eucalyptus globulus essential oil did not also exhibit any toxic effects on HEK293t and HEPG2 cell lines, except in high dose (0.5%) with IC50 = 0.2% for both of the cell lines.
conclusionEucalyptus essential oil showed some side effects and might not be safe to use for treatment at high doses (0.5% and 5%). Moreover, the findings of the present study show that eucalyptus essential oil suppressed the proliferation of human colon cancer cells by inducing apoptosis. Eucalyptus essential oil might be a good candidate for the treatment of colon cancer.
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Registered trials
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