Evidence map›Paper›PMID 33660154›Full record

ArticleObesity surgery2021

Executive Functioning in Extreme Obesity: Contributions from Metabolic Status, Medical Comorbidities, and Psychiatric Factors.

Kyler Mulhauser, Evan L Reynolds, Brian C Callaghan, Cassandra Fierro, Bruno Giordani, Kristen Votruba

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kyler MulhauserUniversity of Michigan, 500 S. State Street, Ann Arbor, MI, 48109, USA. mulhause@med.umich.edu.ORCID http://orcid.org/0000-0003-2755-0451
Evan L ReynoldsUniversity of Michigan, 500 S. State Street, Ann Arbor, MI, 48109, USA.
Brian C CallaghanUniversity of Michigan, 500 S. State Street, Ann Arbor, MI, 48109, USA.
Cassandra FierroUniversity of Michigan, 500 S. State Street, Ann Arbor, MI, 48109, USA.
Bruno GiordaniUniversity of Michigan, 500 S. State Street, Ann Arbor, MI, 48109, USA.
Kristen VotrubaUniversity of Michigan, 500 S. State Street, Ann Arbor, MI, 48109, USA.
State Street (United States) · USUniversity of Michigan · US

Funding

TRAINING IN CLINICAL AND BASIC NEUROSCIENCET32NS007222 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 1985 to 2026
$8.0M
The Effect of High Intensity Interval Training and Surgical Weight Loss On Distal Symmetric Polyneuropathy OutcomesR01DK115687 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CALLAGHAN, BRIAN CHRISTOPHER · 2018 to 2022
$3.1M
NIDDK NIH HHS R01 DK115687NINDS NIH HHS T32 NS007222
6 · The paper itself

Abstract

purposeExtreme obesity has been associated with cognitive deficits across the lifespan and may be a risk factor for dementia in later life. However, the relationship between obesity and domain-specific cognitive deficits is complicated by a body of literature that often fails to adequately account for medical and psychiatric conditions frequently co-occurring with extreme obesity. MATERIALS AND

methodsThe present study included a cross-sectional evaluation of adults with extreme obesity (n=117) compared to lean control (n=46) participants on a brief cognitive battery using the NIH Toolbox and Rey Auditory Verbal Learning Test. Specifically, this study evaluated measures of executive functioning, attention, processing speed, learning, and memory while accounting for many common obesity-related medical and psychiatric comorbidities with known cognitive effects.

resultsResults revealed group differences with lower performances on measures of executive functioning, processing speed, and learning (ps<0.01) for participants with obesity. Reduced executive functioning was associated with abdominal obesity and medication use (ps<0.01) and together contributed significantly to overall modeling of cognition in individuals with obesity.

conclusionIndividuals with extreme obesity in this sample showed lower cognitive performance on measures of executive functioning, processing speed, and learning compared to lean controls. Abdominal obesity was associated with executive functioning deficits independent of many common medical and psychiatric factors.

Indexed as

Obesity, MorbidAdultCognitionCross-Sectional StudiesExecutive FunctionHumansNeuropsychological TestsObesityBariatric surgeryCognitionExecutive functionsExtreme obesity

Identifiers

PMID33660154
PMCPMC11632671
OpenAlexW3134463405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.