Evidence map›Paper›PMID 33660028›Full record

ArticlePflugers Archiv : European journal of physiology2021

The conduction velocity-potassium relationship in the heart is modulated by sodium and calcium.

D Ryan King, Michael Entz, Grace A Blair, Ian Crandell, Alexandra L Hanlon, Joyce Lin, Gregory S Hoeker, Steven Poelzing

Open access · hybridAbstract read
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Emergency management of hyperkalemia in dogs and cats - Part 1: Pathophysiology and etiology.The Canadian veterinary journal = La revue veterinaire canadienne · 2026
    Review
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  6. Electroanatomical adaptations in the guinea pig heart from neonatal to adulthood.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  7. Indirect Correlative Light and Electron Microscopy (iCLEM): A Novel Pipeline for Multiscale Quantification of Structure From Molecules to Organs.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2024
    Article
  8. Article
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  10. Myocardial ischemia simulation based on a multi-scale heart electrophysiology model.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024
    Article
  11. Article
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  14. Is space flight arrhythmogenic?Frontiers in physiology · 2023
    Article
  15. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Epicardial adipose tissue as a mediator of cardiac arrhythmias.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

D Ryan KingTranslational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Michael EntzCenter for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.
Grace A BlairTranslational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Ian CrandellCenter for Biostatistics and Health Data Science, Virginia Polytechnic Institute and State University, Roanoke, VA, USA.
Alexandra L HanlonCenter for Biostatistics and Health Data Science, Virginia Polytechnic Institute and State University, Roanoke, VA, USA.
Joyce LinDepartment of Mathematics, California Polytechnic State University, San Luis Obispo, CA, USA.
Gregory S HoekerCenter for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA.
Steven PoelzingTranslational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA. poelzing@vtc.vt.edu.ORCID http://orcid.org/0000-0002-6979-1264
Carilion Roanoke Memorial Hospital · USVirginia Tech · USCalifornia Polytechnic State University · US

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Role of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9M
Signaling in Inherited and Acquired Sodium Channel Gain of FunctionR01HL138003 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN, WEINBERG, SETH HOWARD · 2018 to 2021
$2.6M
The Role of the Sodium Channel Beta Subunit in Cardiac ConductionR01HL141855 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G, POELZING, STEVEN · 2018 to 2021
$1.8M
Hypernatremic perfusion decreases mechanical and mitochondrial recovery following an ischemic insultF31HL147438 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KING, DAVID RYAN · 2019 to 2020
$67k
NCATS NIH HHS UL1 TR003015NCATS NIH HHS UL1TR003015NHLBI NIH HHS F31 HL147438NHLBI NIH HHS F31-HL147438NHLBI NIH HHS R01 HL102298NHLBI NIH HHS R01-HL102298NHLBI NIH HHS R01 HL138003NHLBI NIH HHS R01-HL138003NHLBI NIH HHS R01 HL141855NHLBI NIH HHS R01-HL141855
6 · The paper itself

Abstract

The relationship between cardiac conduction velocity (CV) and extracellular potassium (K

Indexed as

AnimalsCalciumGuinea PigsHeartHeart Conduction SystemIsolated Heart PreparationPotassiumSodiumCalciumPotassiumSodiumCalciumCardiac ElectrophysiologyHyperkalemiaLangendorffSodium

Identifiers

PMID33660028
PMCPMC7940307
OpenAlexW3134967819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.