Evidence map›Paper›PMID 33659890›Full record

ReviewJHEP reports : innovation in hepatology2021

Case-finding strategies in non-alcoholic fatty liver disease.

Jerome Boursier, Emmanuel A Tsochatzis

Abstract readReview
In one paragraph

Review in JHEP reports : innovation in hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Precision in Liver Diagnosis: Varied Accuracy Across Subgroups and the Need for Variable Thresholds in Diagnosis of MASLD.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Should we undertake surveillance for HCC in patients with MAFLD?Therapeutic advances in endocrinology and metabolism · 2023
    Review
  13. Repeated measurements of non-invasive fibrosis tests to monitor the progression of non-alcoholic fatty liver disease: A long-term follow-up study.Liver international : official journal of the International Association for the Study of the Liver · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Non-alcoholic fatty liver disease: A patient guideline.JHEP reports : innovation in hepatology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jerome BoursierService d'Hépato-Gastroentérologie et Oncologie Digestive, Centre Hospitalier Universitaire d'Angers, Angers, France.
Emmanuel A TsochatzisSheila Sherlock Liver Centre, Royal Free Hospital, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the large population of patients with non-alcoholic fatty liver disease (NAFLD), identifying those with advanced disease remains challenging. Many patients are diagnosed late, following the development of liver-related complications, leading to poor clinical outcomes. Accumulating evidence suggests that using non-invasive tests for liver fibrosis in patients with metabolic risk factors improves the detection of patients in need of specialised management and is cost-effective. Because of the vast number of patients requiring evaluation, the active participation of general practitioners and physicians who manage patients with metabolic disorders, such as diabetologists, is crucial; this calls for the increased awareness of NAFLD beyond liver clinics. Non-invasive case-finding strategies will need to be further validated and generalised for upcoming drug therapies to have the required impact on the worldwide burden of NAFLD.

Indexed as

ALD, alcohol-related liver diseaseALT, alanine aminotransferaseAST, aspartate aminotransferaseAwarenessCase-findingCirrhosisCost-effectivenessElastographyELF, enhanced liver fibrosisFIB-4FIB-4, fibrosis-4GP, general practitionerLiver fibrosisNAFLD, non-alcoholic fatty liver diseaseNASH, non-alcoholic steatohepatitisNAS, NAFLD activity scoreNFS, NAFLD fibrosis scoreNICE, National Institute of Clinical ExcellenceNIT, non-invasive testPatient pathwayPrimary careQALY, quality-adjusted life yearScreeningT2DM, type 2 diabetes mellitusTE, transient elastographyType 2 diabetes mellitus

Identifiers

PMID33659890
PMCPMC7896150

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.