Evidence map›Paper›PMID 33659755›Full record

ArticleHeliyon2021

The migration of metastatic breast cancer cells is regulated by matrix stiffness via YAP signalling.

Wei Chen, Shihyun Park, Chrishma Patel, Yuxin Bai, Karim Henary, Arjun Raha, Saeed Mohammadi, Lidan You, Fei Geng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei ChenDepartment of Mechanical Engineering, McMaster University, Hamilton, ON L8S 0A3, Canada.
Shihyun ParkFaculty of Health Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.
Chrishma PatelFaculty of Health Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.
Yuxin BaiFaculty of Health Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.
Karim HenaryDepartment of Mechanical Engineering, McMaster University, Hamilton, ON L8S 0A3, Canada.
Arjun RahaDepartment of Mechanical Engineering, McMaster University, Hamilton, ON L8S 0A3, Canada.
Saeed MohammadiW Booth School of Engineering Practice and Technology, McMaster University, Hamilton, ON L8S 0A3, Canada.
Lidan YouDepartment of Mechanical & Industrial Engineering, University of Toronto, Toronto, ON M5S 3G8, Canada.
Fei GengDepartment of Mechanical Engineering, McMaster University, Hamilton, ON L8S 0A3, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix stiffness is a driver of breast cancer progression and mechanosensitive transcriptional activator YAP plays an important role in this process. However, the interplay between breast cancer and matrix stiffness, and the significance of this interplay remained largely unknown. Here, we showed an increase in YAP nuclear localization and a higher proliferation rate in both highly metastatic MDA-MB-231 cells and the non-metastatic counterpart MCF-7 cells when they were exposed to the stiff matrix. However, in response to the stiff matrix highly metastatic MDA-MB-231 cells instead of MCF-7 cells exhibited upregulated mobility, which was shown to be YAP-dependent. Consistently, MDA-MB-231 cells exhibited different focal adhesion dynamics from MCF-7 cells in response to matrix stiffness. These results suggested a YAP-dependent mechanism through which matrix stiffness regulates the migratory potential of metastatic breast cancer cells.

Indexed as

Cell mobilityMatrix stiffnessMechanosensingMetastatic breast cancerYAP

Identifiers

PMID33659755
PMCPMC7895759

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.