Evidence map›Paper›PMID 33659753›Full record

ReviewHeliyon2021

Polyphenolic inhibition of enterocytic starch digestion enzymes and glucose transporters for managing type 2 diabetes may be reduced in food systems.

Emmanuel O Ayua, Smith G Nkhata, Sydney J Namaumbo, Elijah Heka Kamau, Theresa N Ngoma, Kevin Omondi Aduol

Open access · goldAbstract readReview
In one paragraph

Review in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 67 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Polyphenols ofACS omega · 2026
    Article
  5. Structure-effect relationship of phenolic compounds onCurrent research in food science · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. The Evolution of Pharmacological ActivitiesPharmaceuticals (Basel, Switzerland) · 2022
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Emmanuel O AyuaDepartment of Food Science and Nutrition, University of Eldoret, P.O Box 1125-30100, Eldoret, Kenya.
Smith G NkhataAgrofood Processing Technology, Faculty of Life Sciences and Natural Resources, Natural Resources College, Lilongwe University of Agriculture and Natural Resources, P. O Box 143, Lilongwe, Malawi.
Sydney J NamaumboAgrofood Processing Technology, Faculty of Life Sciences and Natural Resources, Natural Resources College, Lilongwe University of Agriculture and Natural Resources, P. O Box 143, Lilongwe, Malawi.
Elijah Heka KamauDepartment of Food Science and Nutrition, University of Eldoret, P.O Box 1125-30100, Eldoret, Kenya.
Theresa N NgomaAgrofood Processing Technology, Faculty of Life Sciences and Natural Resources, Natural Resources College, Lilongwe University of Agriculture and Natural Resources, P. O Box 143, Lilongwe, Malawi.
Kevin Omondi AduolDepartment of Food Science and Nutrition, University of Eldoret, P.O Box 1125-30100, Eldoret, Kenya.
Lilongwe University of Agriculture and Natural Resources · MWUniversity of Eldoret · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the current global surge in diabetes cases, there is a growing interest in slowing and managing diabetes and its effects. While there are medications that can be used, they have adverse side effects such as hypoglycemia and weight gain. To overcome these problems, bioactive compounds commonly found in fruits, vegetables and cereal grains are used to slow starch digestion and transport of simple sugars across the intestinal epithelia thereby reducing plasma blood glucose spike. These effects are achieved through inhibition of amylases, glucosidases and glucose transporters present in the gastrointestinal tract and brush boarder membrane. The extent of inhibition by polyphenols is dependent on molecular structure, doses and food matrix. Glycemic lowering effect of polyphenols have been demonstrated both in i

Indexed as

Enzyme inhibitionGlucose transporterPolyphenolsStarch digestionType II diabetes

Identifiers

PMID33659753
PMCPMC7895753
OpenAlexW3129407930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.