Evidence map›Paper›PMID 33659339›Full record

ArticleBio-protocol2020

Protocol for Peptide Synthesis on Spectrally Encoded Beads for MRBLE-pep Assays.

Jamin B Hein, Huy Q Nguyen, Martha Cyert, Polly M Fordyce

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bio-protocol, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Towards rational computational peptide design.Frontiers in bioinformatics · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Jamin B HeinDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Huy Q NguyenDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Martha CyertDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Polly M FordyceDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Stanford University · USChan Zuckerberg Initiative (United States) · USUniversity of Copenhagen · DK

Funding

Systematic elucidation of calcineurin phosphatase signaling in humansR35GM136243 · NIGMS · STANFORD UNIVERSITY · PI Martha S. Cyert · 2020 to 2026
$3.9M
Leveraging spectral encoding for high dimensional biological multiplexingDP2GM123641 · NIGMS · STANFORD UNIVERSITY · PI FORDYCE, POLLY MORRELL · 2016 to 2016
$2.4M
Identifying The Human Calcineurin Signaling NetworkR01GM119336 · NIGMS · STANFORD UNIVERSITY · PI CYERT, MARTHA S. · 2016 to 2019
$2.0M
A Novel Platform for Synthesis of Programmable Proteome-Scale Peptide Bead ArraysR01GM107132 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DORSEY, MORNA J · 2014 to 2018
$1.9M
NIGMS NIH HHS DP2 GM123641NIGMS NIH HHS R01 GM107132NIGMS NIH HHS R01 GM119336NIGMS NIH HHS R35 GM136243
6 · The paper itself

Abstract

Every living cell relies on signal transduction pathways comprised of protein-protein interactions (PPIs). In many cases, these PPIs are between a folded protein domain and a short linear motif (SLiM) within an unstructured region of a protein. As a result of this small interaction interface (3-10 amino acids), the affinities of SLiM-mediated interactions are typically weak (

Indexed as

Binding affinityBinding assayHydrogel beadsPeptide binding assayPeptide synthesisProtein-protein interactionsSLiMsSpectral encoding

Identifiers

PMID33659339
PMCPMC7842318
OpenAlexW3038809482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.