Evidence map›Paper›PMID 33659302›Full record

ArticleBio-protocol2020

Analysis of Generalized Fibrosis in Mouse Tissue Sections with Masson's Trichrome Staining.

Diantha Van De Vlekkert, Eda Machado, Alessandra d'Azzo

Open access · greenAbstract read
In one paragraph

Article in Bio-protocol, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 115 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Diantha Van De VlekkertDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Eda MachadoDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Alessandra d'AzzoDepartment of Genetics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
St. Jude Children's Research Hospital · US

Funding

Gene Transfer for Galactosialidosis - ResubR01DK095169 · NIDDK · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI D'AZZO, ALESSANDRA · 2013 to 2016
$2.8M
Excessive Lysosomal Exocytosis Triggers Pathogenic Mechanisms in Sialidosis MiceR01GM104981 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI D'AZZO, ALESSANDRA · 2013 to 2017
$1.4M
NIDDK NIH HHS R01 DK095169NIGMS NIH HHS R01 GM104981
6 · The paper itself

Abstract

Expansion of fibrous connective tissue and abnormal deposition of extracellular matrix (ECM) are at the basis of many fibrotic diseases. Fibrosis can occur in response to both physiological and pathological cues, including wound healing, tissue remodeling/repair and inflammation. Chronic fibrosis can lead to severe tissue damage, organ failure and death. Assessing the extent of organ fibrosis is crucial for accurate diagnosis of this condition. The use of Masson's trichrome staining of tissue sections from skeletal muscle is a fast method for detection of morphological alterations indicative of a fibrotic phenotype in this organ. This staining method detects the extent of collagen fibers deposition and, because it employs the combination of three dyes, can also distinguish muscle fibers (red), from collagen (blue) and nuclei (black), simultaneously.

Indexed as

CollagenFibroblastsFibrosisMasson’s TrichromeSkeletal muscleTissue section

Identifiers

PMID33659302
PMCPMC7842772
OpenAlexW3026506096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.