Evidence map›Paper›PMID 33659279›Full record

ReviewFrontiers in cardiovascular medicine2021

Development and Application of Endothelial Cells Derived From Pluripotent Stem Cells in Microphysiological Systems Models.

Crystal C Kennedy, Erin E Brown, Nadia O Abutaleb, George A Truskey

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Advances in human induced pluripotent stem cell (hiPSC)-based disease modelling in cardiogenetics.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Human CD34Leukemia · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Crystal C KennedyUniversity Program in Genetics and Genomics, Duke University, Durham, NC, United States.
Erin E BrownDepartment of Biomedical Engineering, Duke University, Durham, NC, United States.
Nadia O AbutalebDepartment of Biomedical Engineering, Duke University, Durham, NC, United States.
George A TruskeyDepartment of Biomedical Engineering, Duke University, Durham, NC, United States.
Duke University · US

Funding

In Vitro Human Tissue-Engineered Blood Vessel Disease Model of ProgeriaR01HL138252 · NHLBI · DUKE UNIVERSITY · PI TRUSKEY, GEORGE A · 2017 to 2025
$4.7M
Vascular, Cardiac, and Lung Alveolar Human Microphysiological Systems for SARS-CoV-2 Drug ScreeningUH3TR002142 · NCATS · DUKE UNIVERSITY · PI TRUSKEY, GEORGE A · 2019 to 2021
$4.0M
Progeria and Vasculature: Investigating Genetic Effects and the Potential of Genome Editing for TreatmentF31HL152651 · NHLBI · DUKE UNIVERSITY · PI KENNEDY, CRYSTAL · 2020 to 2022
$138k
NCATS NIH HHS UH3 TR002142NHLBI NIH HHS F31 HL152651NHLBI NIH HHS R01 HL138252
6 · The paper itself

Abstract

The vascular endothelium is present in all organs and blood vessels, facilitates the exchange of nutrients and waste throughout different organ systems in the body, and sets the tone for healthy vessel function. Mechanosensitive in nature, the endothelium responds to the magnitude and temporal waveform of shear stress in the vessels. Endothelial dysfunction can lead to atherosclerosis and other diseases. Modeling endothelial function and dysfunction in organ systems

Indexed as

cell differentiationinduced pluripotent stem cellsorganoidsvascular endotheliumvascular tissue engineering

Identifiers

PMID33659279
PMCPMC7917070
OpenAlexW3132114329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.