ReviewFrontiers in cell and developmental biology2021
Emotion Induced Monoamine Neuromodulator Release Affects Functional Neurological Disorders.
Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A Chain mediation model linking experiential avoidance, cognitive flexibility, negative emotions, and sleep quality in university students.Scientific reports · 2026Article
- Unraveling functional neurological disorder in pediatric populations: A systematic review of diagnosis, treatment, and outcomes.World journal of clinical pediatrics · 2025Article
- Psychological assessment and support in functional neurological disorder: a longitudinal study.Frontiers in psychology · 2025Article
- Understanding Functional Neurological Disorder: Recent Insights and Diagnostic Challenges.International journal of molecular sciences · 2024Review
- Neuromodulation of safety and surprise in the early stages of infant development: affective homeostatic regulation in bodily and mental functions.Frontiers in psychology · 2024Review
- Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice.Nature communications · 2023Article
- Role of Stress-Related Dopamine Transmission in Building and Maintaining a Protective Cognitive Reserve.Brain sciences · 2022Review
- Editorial: Natural products and brain energy metabolism: Astrocytes in neurodegenerative diseases.Frontiers in pharmacology · 2022Article
- The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression.Frontiers in psychiatry · 2022Review
- Article
- Neurotransmitters and Electrophysiological Changes Might Work as Biomarkers for Diagnosing Affective Disorders.Disease markers · 2021Article
- The Aversion Function of the Limbic Dopaminergic Neurons and Their Roles in Functional Neurological Disorders.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional neurologic disorders (FNDs), also called conversion disorder (previously called hysteria), can show almost all the symptoms of other neurological diseases, including both physical (for example, seizure, weakness, fatigue) and psychological (for instance, depression, anxiety) symptoms. In spite of our general knowledge about emotional processes and developmental defects in the formation of these somatic symptoms, there is still no systemic and comprehensive research on the effects of emotional developmental variables in FND. Recently, both experimental and theoretical emotion studies have been greatly increased, such as prediction error, conceptual act model, basic emotional theory, and monoamine neuromodulator based three primary emotions. In addition, a large amount of evidence has confirmed the role of psychosocial adversity (such as stressful life events, interpersonal difficulties) as an important risk factor for FND. Here, we review recent advances about emotional stress on FND, and pay special attention to the effects of monoamine neuromodulators, such as how norepinephrine and serotonin affect behaviors. Then, we discuss the significance of these changes for FND, which may contribute to clarifying the pathogenesis of FND, and thus provide potential therapeutic drug targets or psychological intervention methods in the future.
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