ArticleBiomedical optics express2021
Lightsheet-based flow cytometer for whole blood with the ability for the magnetic retrieval of objects from the blood flow.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Minimally Invasive Endovascular Administration for Targeted PLGA Nanoparticles Delivery to Brain, Salivary Glands, Kidney and Lower Limbs.Pharmaceutics · 2026Article
- The Influence of Magnetic Composite Capsule Structure and Size on Their Trapping Efficiency in the Flow.Molecules (Basel, Switzerland) · 2022Article
- Renal Artery Catheterization for Microcapsules' Targeted Delivery to the Mouse Kidney.Pharmaceutics · 2022Article
- Effect of Size on Magnetic Polyelectrolyte Microcapsules Behavior: Biodistribution, Circulation Time, Interactions with Blood Cells and Immune System.Pharmaceutics · 2021Article
- Optical coherence microangiography of the mouse kidney for diagnosis of circulatory disorders.Biomedical optics express · 2021Article
- Serial imaging of micro-agents and cancer cell spheroids in a microfluidic channel using multicolor fluorescence microscopy.PloS one · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
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Abstract
Detection and extraction of circulating tumor cells and other rare objects in the bloodstream are of great interest for modern diagnostics, but devices that can solve this problem for the whole blood volume of laboratory animals are still rare. Here we have developed SPIM-based lightsheet flow cytometer for the detection of fluorescently-labeled objects in whole blood. The bypass channel between two blood vessels connected with the external flow cell was used to visualize, detect, and magnetically separate fluorescently-labeled objects without hydrodynamic focusing. Carriers for targeted drug delivery were used as model objects to test the device performance. They were injected into the bloodstream of the rat, detected fluorescently, and then captured from the bloodstream by a magnetic separator prior to filtration in organs. Carriers extracted from the whole blood were studied by a number of
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Registered trials
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