ArticleBiomedical optics express2021
Linear diattenuation imaging of biological tissues with near infrared Mueller scanning microscopy.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Shadowless amyloid imaging with quantitative birefringence contrast.Scientific reports · 2025Article
- Reconstructing Three-Dimensional Optical Anisotropy with Tomographic Müller-Polarimetric Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Backscattering Mueller matrix polarimetry estimates microscale anisotropy and orientation in complex brain tissue structure.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Controlling the broadband enhanced light chirality with L-shaped dielectric metamaterials.Nature communications · 2024Article
- Mechanical stability of polarization signatures in biological tissue characterization.Biomedical optics express · 2024Article
- High-fidelity and rapid cellular-level Mueller matrix imaging for tissue identification with unstained sections.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among the multitude of optical polarization contrasts that can be observed in complex biological specimens, linear diattenuation (LD) imaging has received little attention. It is indeed challenging to image LD with basic polarizing microscopes because it is often relatively small in comparison with linear retardance (LR). In addition, interpretation of LD images is not straightforward when experiments are conducted in the visible range because LD can be produced by both dichroism and anisotropic scattering. Mueller polarimetry is a powerful implementation of polarization sensing able to differentiate and measure the anisotropies of specimens. In this article, near infrared transmission Mueller scanning microscopy is used to image LD in thin biological specimen sections made of various proteins with unprecedented resolution and sensitivity. The near infrared spectral range makes it possible to lower the contribution of dichroism to the total linear diattenuation in order to highlight anisotropic scattering. Pixel-by-pixel comparison of LD images with LR and multiphoton images demonstrates that LD is produced by under-resolved structures that are not revealed by other means, notably within the sarcomere of skeletal muscles. LD microscopy appears as a powerful tool to provide new insights into the macro-molecular organization of biological specimens at the sub-microscopic scale without labelling.
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Registered trials
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