ArticleFrontiers in genetics2021
Delineation of Mitochondrial DNA Variants From Exome Sequencing Data and Association of Haplogroups With Obesity in Kuwait.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Mitochondrial haplogroup M contributes to asthma risk in the Kuwaiti population.Frontiers in allergy · 2025Article
- Nucleic acid degradation after long-term dried blood spot storage.Molecular ecology resources · 2024Article
- Mitochondrial haplogroup R offers protection against obesity in Kuwaiti and Qatari populations.Frontiers in endocrinology · 2024Article
- Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs.Frontiers in endocrinology · 2024Article
- Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity.International journal of molecular sciences · 2023Review
- Editorial: Population and ancestry specific variation in disease susceptibility.Frontiers in genetics · 2023Article
- Heterogeneity in biomarkers, mitogenome and genetic disorders of the Arab population with special emphasis on large-scale whole-exome sequencing.Archives of medical science : AMS · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
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Abstract
BACKGROUND/
objectivesWhole-exome sequencing is a valuable tool to determine genetic variations that are associated with rare and common health conditions. A limited number of studies demonstrated that mitochondrial DNA can be captured using whole-exome sequencing. Previous studies have suggested that mitochondrial DNA variants and haplogroup lineages are associated with obesity. Therefore, we investigated the role of mitochondrial variants and haplogroups contributing to the risk of obesity in Arabs in Kuwait using exome sequencing data. SUBJECTS/
methodsIndirect mitochondrial genomes were extracted from exome sequencing data from 288 unrelated native Arab individuals from Kuwait. The cohort was divided into obese [body mass index (BMI) ≥ 30 kg/m
resultsHaplogroup R showed a protective effect on obesity [odds ratio (OR) = 0.311;
conclusionsThis is the first to utilize whole-exome data to extract entire mitochondrial haplogroups to study its association with obesity in an Arab population.
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