Evidence map›Paper›PMID 33659011›Full record

ArticleFrontiers in immunology2021

An Anti-Tumor Vaccine Against Marek's Disease Virus Induces Differential Activation and Memory Response of γδ T Cells and CD8 T Cells in Chickens.

Xiaoli Hao, Shuai Li, Jiaqi Li, Yi Yang, Aijian Qin, Shaobin Shang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaoli HaoCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Shuai LiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Jiaqi LiCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Yi YangCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Aijian QinCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Shaobin ShangCollege of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Yangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes deadly T-cell lymphomas and serves as a natural virus-induced tumor model in chickens. The most efficacious vaccine, CVI988/Rispens (CVI988), against MD has been used for several decades. However, the mechanisms leading to protective immunity following vaccination are not fully understood. In this study, employing multi-parameter flow cytometry, we performed a comprehensive analysis of T cell responses in CVI988-vaccinated chickens. CVI988 vaccination induced significant expansion of γδ T cells and CD8α

Indexed as

ChickensPoultry DiseasesAnimalsCancer VaccinesCD8-Positive T-LymphocytesHerpesvirus 2, GallidMarek DiseaseReceptors, Antigen, T-Cell, gamma-deltaVaccinationViral VaccinesCancer VaccinesReceptors, Antigen, T-Cell, gamma-deltaViral VaccinesCD8 T cellimmune responseMDVvaccineγδ T cell

Identifiers

PMID33659011
PMCPMC7917234
OpenAlexW3130596558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.