Evidence map›Paper›PMID 33658993›Full record

ArticleFrontiers in immunology2020

TRPM7 Kinase Is Essential for Neutrophil Recruitment and Function

Wiebke Nadolni, Roland Immler, Kilian Hoelting, Marco Fraticelli, Myriam Ripphahn, Simone Rothmiller, Masayuki Matsushita, Ingrid Boekhoff, Thomas Gudermann, Markus Sperandio and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Inter-Organellar CaCells · 2025
    Review
  7. MgJournal of cellular physiology · 2025
    Article
  8. TRP Ion Channels in Immune Cells and Their Implications for Inflammation.International journal of molecular sciences · 2024
    Review
  9. Article
  10. How Bacterial Pathogens Coordinate Appetite with Virulence.Microbiology and molecular biology reviews : MMBR · 2023
    Review
  11. Article
  12. Article
  13. ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis.International journal of molecular sciences · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Wiebke NadolniWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Roland ImmlerWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Munich, Germany.
Kilian HoeltingWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Marco FraticelliWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Myriam RipphahnWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Munich, Germany.
Simone RothmillerBundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.
Masayuki MatsushitaDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Ingrid BoekhoffWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Thomas GudermannWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Markus SperandioWalter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Munich, Germany.
Susanna ZierlerWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.
Ludwig-Maximilians-Universität München · DEInstitut für Pharmakologie und Toxikologie der BundeswehrUniversity of the Ryukyus · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During inflammation, neutrophils are one of the first responding cells of innate immunity, contributing to a fast clearance of infection and return to homeostasis. However, excessive neutrophil infiltration accelerates unsolicited disproportionate inflammation for instance in autoimmune diseases such as rheumatoid arthritis. The

Indexed as

Neutrophil InfiltrationAnimalsCells, CulturedDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, KnockoutNeutrophilsPeritonitisProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSignal TransductionTOR Serine-Threonine KinasesTRPM Cation ChannelsAKT1 protein, humanAkt1 protein, mouseMTOR protein, humanmTOR protein, mouseProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesTOR Serine-Threonine KinasesTRPM7 protein, humanTrpm7 protein, mouseTRPM Cation ChannelsTumor Necrosis Factor-alphachemotaxisinflammationinnate immunityion channelkinasemigrationneutrophils (PMNs)TRPM7

Identifiers

PMID33658993
PMCPMC7917126
OpenAlexW3129330919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.