Evidence map›Paper›PMID 33658911›Full record

ArticleFrontiers in molecular neuroscience2021

Insights Into the Mechanism of Tyrosine Nitration in Preventing β-Amyloid Aggregation in Alzheimer's Disease.

Jie Zhao, Qihui Shi, Ye Zheng, Qiulian Liu, Zhijun He, Zhonghong Gao, Qiong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jie ZhaoShenzhen Key Laboratory of Marine Bioresource and Eco-environmental Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
Qihui ShiShenzhen Key Laboratory of Marine Bioresource and Eco-environmental Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
Ye ZhengShenzhen Key Laboratory of Marine Bioresource and Eco-environmental Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
Qiulian LiuShenzhen Key Laboratory of Marine Bioresource and Eco-environmental Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
Zhijun HeShenzhen Key Laboratory of Marine Bioresource and Eco-environmental Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
Zhonghong GaoHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China.
Qiong LiuShenzhen Key Laboratory of Marine Bioresource and Eco-environmental Sciences, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitration of tyrosine at the tenth residue (Tyr10) in amyloid-β (Aβ) has been reported to reduce its aggregation and neurotoxicity in our previous studies. However, the exact mechanism remains unclear. Here, we used Aβ

Indexed as

Alzheimer’s diseaseAβfibrilizationprotein modificationtyrosine nitration

Identifiers

PMID33658911
PMCPMC7917295

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.