ArticleClinical epidemiology2021
Incidence and Survival for Head and Neck Cancers in Estonia, 1996-2016: A Population-Based Study.
Article in Clinical epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Changing burden of cancers related to human papillomavirus in Estonia: a population-based registry study.Acta oncologica (Stockholm, Sweden) · 2026Article
- Global, regional and national burden of lip and oral cavity cancer from 1990 to 2021 and projections to 2036.BMC oral health · 2025Article
- Development of a quantitative genomic instability scoring system and a related competing endogenous RNA network in head and neck squamous cell carcinoma.Translational cancer research · 2025Article
- Survival in oral and pharyngeal cancers is catching up with laryngeal cancer in the NORDIC countries through a half century.Cancer medicine · 2024Article
- Establishment of a prognostic model for hypoxia-associated genes in OPSCC and revelation of intercellular crosstalk.Frontiers in immunology · 2024Article
- Multi-omics characterization of a scoring system to quantify hypoxia patterns in patients with head and neck squamous cell carcinoma.Journal of translational medicine · 2023Article
- GAPDH: unveiling its impact as a key hypoxia-related player in head and neck squamous cell carcinoma tumor progression, prognosis, and therapeutic potential.American journal of cancer research · 2023Article
- Review
- Incidence and mortality rates of lip, oral cavity, and pharynx cancers in Brazil: time-trend and age-period-cohort analysis from the last 30 years, Global Burden of Disease Study.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- Role of IGF2BPs in head and neck squamous cell carcinoma.Frontiers in oncology · 2022Review
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4 authors.
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Abstract
backgroundChanging patterns of alcohol and tobacco consumption and human papillomavirus (HPV) infection have affected the epidemiology of head and neck cancers. The aim of this study was to examine 20-year trends in the incidence and survival of head and neck cancers in Estonia by site, sex, morphology, and stage.
methodsData on all adult cases of invasive head and neck cancers diagnosed in Estonia in 1996-2016 were obtained from a population-based cancer registry. TNM stage was available for 2010-2016. Incidence trends were modeled with join-point regression, and five-year relative survival ratios (RSRs) were calculated.
resultsA total of 6,769 cases were included, 64% men. We observed declining incidence of lip and laryngeal cancer and substantial increases in the incidence of hypopharyngeal and oropharyngeal cancers. Over 60% of mouth and pharyngeal cancers were diagnosed at stage IV. Age-standardized 5-year RSR for mouth and pharyngeal cancer increased substantially over the study period, from 21% (95% CI 16%-25%) in 1996-2002 to 33% (29%-38%) in 2010-2016. The largest survival increases were seen for cancers of the oral cavity (reaching 44% in 2010-2016), tongue (41%), and larynx (63%), while modest changes were seen for the oropharynx (24%) and hypopharynx (17%). The latest 5-year RSR was 90% for thyroid cancers (99% for papillary carcinoma). Large female survival advantage was seen for most sites.
conclusionThe observed trends suggest an emerging role of HPV infection in combination with traditional risk factors in the development of head and neck cancers in Estonia. Efforts targeting health behavior, HPV vaccination, and earlier diagnosis are crucial for reducing mortality from these cancers.
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