Evidence map›Paper›PMID 33658786›Full record

ArticleNeuropsychiatric disease and treatment2021

The Analysis of Anxiety and Depression in Different Stages of in vitro Fertilization-Embryo Transfer in Couples in China.

Yao-Fang Liu, Zheng Fu, Shao-Wei Chen, Xiao-Ping He, Ling-Ye Fan

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Neuropsychiatric disease and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 6 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06084793 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Music Before and During an Embryo Transfer on the Anxiety and Satisfaction Levels: An Open-label Randomized Controlled Trial

TypeinterventionalSponsorCentro de Estudios en Genetica y ReproduccionRan2023 to 2024Enrolled146ConditionsREPRODUCTIVE TECHNIQUES, Embryo Transfer, Music, Test AnxietyArmsMusic
NCT06475690 nacompletednot on this mapstarted 2024, after this paper: background citation

the Psychological Interventions for Alleviating Anxiety and Depressive Emotion Among Oocyte Retrieval Patients

TypeinterventionalSponsorFirst Affiliated Hospital of Chongqing Medical UniversityRan2024 to 2025Enrolled180ConditionsInfertility, in Vitro Fertilization, Mental Health, Anesthesia, GeneralArmsPsychological interventions
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 6 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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  4. Effects ofFrontiers in reproductive health · 2025
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  7. [Correlational research on body fat rate and skeletal muscle rate with depression in the population of assisted reproduction].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
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  18. Effect of anxiety and depression levels on pregnancy outcome.Revista da Associacao Medica Brasileira (1992) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yao-Fang LiuDepartment of Reproductive Technology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China.
Zheng FuDepartment of Reproductive Technology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China.
Shao-Wei ChenDepartment of Reproductive Technology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China.
Xiao-Ping HeDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China.
Ling-Ye FanDepartment of Reproductive Technology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China.ORCID 0000-0003-0530-1593
Affiliated Hospital of Southwest Medical University · CNSouthwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to examine the differences in anxiety and depression between infertile Chinese couples in diverse stages of in vitro fertilization-embryo transfer (IVF-ET) and their relationship with the IVF-ET outcomes.

methodsFrom February 2016 to December 2018, a total of 247 couples that were undergoing IVF-ET were randomly selected for this study. On the day they started their treatment (T1), the day human chorionic gonadotropin was administered (T2), and 4 days after the embryo transfer (T3), self-designed questionnaires, the Self-Rating Anxiety Scale, and the Self-Rating Depression Scale were completed to investigate anxiety and depression in different stages.

resultsAge had an effect on the anxiety and depression in women. Male infertility type and the cause of infertility had an effect on the anxiety and depression in men. The incidence of anxiety in women in the T1, T2, and T3 stages was 29.96%, 44.94%, and 17.81%, respectively. The anxiety scores of women were 46.14 ± 8.37, 50.83 ± 8.50, and 44.09 ± 8.17, respectively, which were significantly higher than those of men (p < 0.05). The anxiety score in stage T2 was the highest in women, and the depression score of women in stage T1 was the highest. The incidence of anxiety in men in the T1, T2, and T3 stages was 20.65%, 8.50%, and 6.07%, respectively. The incidence of anxiety was not significantly different in diverse stages (p > 0.05), and the same result was obtained for the incidence of depression. The anxiety and depression scores of the infertile couples in different stages were not related to the outcome of IVF-ET.

conclusionThe incidence of anxiety and depression in infertile couples in diverse stages of IVF-ET is different, especially in women, and the anxiety and depression of infertile couples in the process of IVF-ET may not be related to the outcome of assisted pregnancy.

Indexed as

anxietycoupledepressionin vitro fertilization-embryo transferoutcome

Identifiers

PMID33658786
PMCPMC7920591
OpenAlexW3130626218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.