Evidence map›Paper›PMID 33658776›Full record

ArticleInternational journal of chronic obstructive pulmonary disease

Undiagnosed and Misdiagnosed Chronic Obstructive Pulmonary Disease: Data from the BOLD Australia Study.

Kate Petrie, Brett G Toelle, Richard Wood-Baker, Graeme P Maguire, Alan L James, Michael Hunter, David P Johns, Guy B Marks, Johnson George, Michael J Abramson

Open access · goldAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Diagnostic performance of FEVChronic respiratory disease
    Pooled it
  3. Article
  4. Article
  5. COPD in Never-Smokers: BOLD Australia Study.International journal of chronic obstructive pulmonary disease · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Different Case Finding Approaches to Optimise COPD Diagnosis: Evidence from the RADICALS Trial.International journal of chronic obstructive pulmonary disease · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Kate PetrieCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Brett G ToelleWoolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0002-7375-0019
Richard Wood-BakerCollege of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.
Graeme P MaguireWestern Clinical School, University of Melbourne, Melbourne, Australia and General Internal Medicine, Western Health, Melbourne, VIC, Australia.ORCID 0000-0003-3817-4885
Alan L JamesSir Charles Gairdner Hospital, West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Perth, WA, Australia.
Michael HunterSchool of Population and Global Health, University of Western Australia, Perth, WA, Australia.ORCID 0000-0001-6704-4815
David P JohnsCollege of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.ORCID 0000-0002-1575-6850
Guy B MarksWoolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.
Johnson GeorgeCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia.
Michael J AbramsonSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-9954-0538
Monash University · AUThe University of Sydney · AUThe University of Western Australia · AUUniversity of Tasmania · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSpirometry is necessary to confirm COPD, but many patients are diagnosed based on clinical presentation and/or chest x-ray. There are also those who do not present to primary care for case finding and remain undiagnosed. We aimed to identify: (a) factors that are associated with undiagnosed COPD; and (b) factors that are associated with a potential misdiagnosis of COPD. PATIENTS AND

methodsThis analysis used data from the Burden of Obstructive Lung Disease (BOLD), a cross-sectional study of community dwelling adults randomly selected from six study sites, chosen to provide a representative sample of the Australian population (n= 3357). Participants were grouped by COPD diagnostic criteria based on spirometry and self-reported diagnosis. Odds ratios for predictors of undiagnosed and misdiagnosed were estimated using logistic regression.

resultsOf the BOLD Australia sample, 1.8% had confirmed COPD, of whom only half self-reported a diagnosis of COPD. A further 6.9% probably had COPD, but were undiagnosed. The priority target population for case finding of undiagnosed COPD was aged ≥60 years (particularly those ≥75 years), with wheezing, shortness of breath and a body mass index (BMI) <25kg/m

conclusionChallenges continue in accurately diagnosing COPD and greater efforts are needed to identify undiagnosed and misdiagnosed individuals to ensure an accurate diagnosis and the initiation of appropriate management in order to reduce the burden of COPD.

Indexed as

Pulmonary Disease, Chronic ObstructiveAdultAustraliaCross-Sectional StudiesDiagnostic ErrorsFemaleHumansRisk FactorsSpirometrycase findingdiagnosisepidemiologyspirometry

Identifiers

PMID33658776
PMCPMC7920499
OpenAlexW3132370036

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.