ArticleScientific reports2021
Combination of lymphocyte count and albumin concentration as a new prognostic biomarker for rectal cancer.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 49 citations in OpenAlex.
- Impact of Postoperative Infectious Complications on Long-Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era.Annals of gastroenterological surgery · 2026Article
- Platelet-to-lymphocyte ratio as an indicator of idiopathic epilepsy in dogs.Journal of veterinary internal medicine · 2026Article
- Association between preoperative inflammatory biomarkers and postoperative morbidity and mortality in stage I-III colorectal cancer patients: a single-centre prospective study.BMJ connections surgery · 2026Article
- Integrating the lymphocyte-albumin score into prognostic stratification of nasopharyngeal carcinoma patients treated with concurrent chemoradiotherapy.Frontiers in physiology · 2026Article
- Combination of albumin-lymphocyte score and skeletal muscle index predicts prognosis of patients with ovarian cancer after primary debulking surgery.Frontiers in immunology · 2026Article
- Elevated C-Reactive Protein-Albumin-Lymphocyte Index Is Associated With Reduced Mortality in Chronic Inflammatory Airway Diseases: A Population-Based Observational Study.Mediators of inflammation · 2026Observational
- Albumin-related nutritional indices and all-cause and cause-specific mortality in older adults with severe dysphagia receiving artificial feeding.Frontiers in nutrition · 2025Article
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- Predictive value of preoperative routine examination for the prognosis of patients with pT2N0M0 or pT3N0M0 colorectal cancer.World journal of gastrointestinal oncology · 2024Article
- Multi-omic analysis identifies hypoalbuminemia as independent biomarker of poor outcome upon PD-1 blockade in metastatic melanoma.Scientific reports · 2024Article
- Evaluation of the covariation between leukotriene B4, prostaglandin E2, and hematologic inflammatory parameters in a canine pentylenetetrazole-induced seizure model.Frontiers in neuroscience · 2024Article
- Nomogram incorporating Epstein-Barr virus DNA and a novel immune-nutritional marker for survival prediction in nasopharyngeal carcinoma.BMC cancer · 2023Article
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- A Novel Albumin-Related Nutrition Biomarker Predicts Breast Cancer Prognosis in Neoadjuvant Chemotherapy: A Two-Center Cohort Study.Nutrients · 2023Article
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- A narrative review of prognostic indices in the evaluation of gastrointestinal cancers.Journal of gastrointestinal oncology · 2023Review
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- The potential of high-order features of routine blood test in predicting the prognosis of non-small cell lung cancer.BMC cancer · 2023Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although numerous studies have highlighted the prognostic values of various inflammation-related markers, clinical significance remains to be elucidated. The prognostic values of inflammation-related biomarkers for rectal cancer were investigated in this study. A total of 448 patients with stage II/III rectal cancer undergoing curative resection were enrolled from the discovery cohort (n = 240) and validation cohort (n = 208). We comprehensively compared the prognostic values of 11 inflammation-related markers-derived from neutrophil, lymphocyte, platelet, monocyte, albumin, and C-reactive protein for overall survival (OS) and recurrence-free survival (RFS). Among 11 inflammation-related markers, only "lymphocyte × albumin (LA)" was significantly associated with both OS and RFS in the discovery cohort (P = 0.007 and 0.015, respectively). Multivariate analysis indicated that low LA was significantly associated with poor OS (hazard ratio [HR] 2.19, 95% confidence interval [CI] 1.09-4.58, P = 0.025), and poor RFS (HR 1.61, 95% CI 1.01-2.80, P = 0.048). Furthermore, using the discovery cohort, we confirmed that low LA was significantly associated with poor OS (HR 2.89, 95% CI 1.42-6.00, P = 0.002), and poor RFS (HR 1.79, 95% CI 1.04-2.95, P = 0.034). LA can be a novel prognostic biomarker for stage II/III rectal cancer.
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