ArticleScientific reports2021
Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Temporal properties of direct current sensory block of the rat sciatic nerve using the C-fiber reflex.Journal of neural engineering · 2025Article
- Application of kilohertz-frequency block to mitigate off-target motor effects of vagus nerve stimulation in swine.Nature communications · 2025Article
- PyFibers: An open-source NEURON-Python package to simulate responses of model nerve fibers to electrical stimulation.PLoS computational biology · 2025Article
- Closed-loop electrical block of vagus nerve scales from rodent to porcine cardiac models.Journal of neural engineering · 2025Article
- Ramped kilohertz-frequency signals produce nerve conduction block without onset response.Journal of neural engineering · 2025Article
- Fascicle-selective kilohertz-frequency neural conduction block with longitudinal intrafascicular electrodes.Journal of neural engineering · 2025Article
- Computational modeling of autonomic nerve stimulation: Vagus et al.Current opinion in biomedical engineering · 2024Article
- Highly efficient modeling and optimization of neural fiber responses to electrical stimulation.Nature communications · 2024Article
- NRV: An open framework for in silico evaluation of peripheral nerve electrical stimulation strategies.PLoS computational biology · 2024Article
- Membrane depolarization mediates both the inhibition of neural activity and cell-type-differences in response to high-frequency stimulation.Communications biology · 2024Article
- Peripheral direct current reduces naturally evoked nociceptive activity at the spinal cord in rodent models of pain.Journal of neural engineering · 2024Article
- NRV: An open framework forbioRxiv : the preprint server for biology · 2024Article
- Spatiotemporal parameters for energy efficient kilohertz-frequency nerve block with low onset response.Journal of neuroengineering and rehabilitation · 2023Article
- Characterization of the electrical properties of mammalian peripheral nerve laminae.Artificial organs · 2023Article
- In-vivo application of low frequency alternating currents on porcine cervical vagus nerve evokes reversible nerve conduction block.Bioelectronic medicine · 2021Article
- kHz-frequency electrical stimulation selectively activates small, unmyelinated vagus afferents.Brain stimulationArticle
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Authors and funding
3 authors.
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Abstract
Reversible block of nerve conduction using kilohertz frequency electrical signals has substantial potential for treatment of disease. However, the ability to block nerve fibers selectively is limited by poor understanding of the relationship between waveform parameters and the nerve fibers that are blocked. Previous in vivo studies reported non-monotonic relationships between block signal frequency and block threshold, suggesting the potential for fiber-selective block. However, the mechanisms of non-monotonic block thresholds were unclear, and these findings were not replicated in a subsequent in vivo study. We used high-fidelity computational models and in vivo experiments in anesthetized rats to show that non-monotonic threshold-frequency relationships do occur, that they result from amplitude- and frequency-dependent charge imbalances that cause a shift between kilohertz frequency and direct current block regimes, and that these relationships can differ across fiber diameters such that smaller fibers can be blocked at lower thresholds than larger fibers. These results reconcile previous contradictory studies, clarify the mechanisms of interaction between kilohertz frequency and direct current block, and demonstrate the potential for selective block of small fiber diameters.
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