Trial reportScientific reports2021
Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis.
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between Blood Pressure and Post-Stroke Cognitive Impairment: A Meta-Analysis.Reviews in cardiovascular medicine · 2024Pooled it
- Blood pressure variability and cognitive dysfunction: A systematic review and meta-analysis of longitudinal cohort studies.Journal of clinical hypertension (Greenwich, Conn.) · 2021Pooled it
- Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST.Journal of human hypertension · 2024Trial
- Blood pressure variability and the risk of post-stroke cognitive impairment following atrial fibrillation related acute ischemic stroke.Clinical hypertension · 2026Article
- Article
- Knowledge domain and emerging trends in post-stroke cognitive impairment: a bibliometric analysis.Frontiers in aging neuroscience · 2025Article
- Article
- Blood pressure variability supersedes heart rate variability as a real-world measure of dementia risk.Scientific reports · 2024Article
- Risk factors for cardiovascular and cerebrovascular events in patients with uremia and hypertension during maintenance hemodialysis.American journal of translational research · 2024Article
- Biological Risk Factors Influencing Vascular Cognitive Impairments: A Review of the Evidence.Brain sciences · 2023Review
- Association of blood pressure variability during acute care hospitalization and incident dementia.Frontiers in neurology · 2023Article
- Role of ambulatory blood pressure monitoring in elderly hypertensive patients.Clinical hypertension · 2022Review
- When cognitive impairment has a vascular origin.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Burden and correlates of cognitive impairment among hypertensive patients in Tanzania: a cross-sectional study.BMC neurology · 2021Article
- Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment.Biomedicines · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood pressure variability (BPV) is associated with higher cardiovascular morbidity risks; however, its association with cognitive decline remains unclear. We investigated whether higher BPV is associated with faster declines in cognitive function in ischemic stroke (IS) patients. Cognitive function was evaluated between April 2010 and August 2015 using the Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment in 1,240 Korean PICASSO participants. Patients for whom baseline and follow-up cognitive test results and at least five valid BP readings were available were included. A restricted maximum likelihood-based Mixed Model for Repeated Measures was used to compare changes in cognitive function over time. Among a total of 746 participants (64.6 ± 10.8 years; 35.9% female). Baseline mean-MMSE score was 24.9 ± 4.7. The median number of BP readings was 11. During a mean follow-up of 2.6 years, mean baseline and last follow-up MMSE scores were 25.4 ± 4.8 vs. 27.8 ± 4.4 (the lowest BPV group) and 23.9 ± 5.2 vs. 23.2 ± 5.9 (the highest BPV group). After adjusting for multiple variables, higher BPV was independently associated with faster cognitive decline over time. However, no significant intergroup difference in cognitive changes associated with mean systolic BP was observed. Further research is needed to elucidate how BPV might affect cognitive function.
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