Evidence map›Paper›PMID 33658510›Full record

ArticleNature communications2021

Global profiling of distinct cysteine redox forms reveals wide-ranging redox regulation in C. elegans.

Jin Meng, Ling Fu, Keke Liu, Caiping Tian, Ziyun Wu, Youngeun Jung, Renan B Ferreira, Kate S Carroll, T Keith Blackwell, Jing Yang

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 109 citations in OpenAlex.

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  15. Ribosome Assembly and Repair.Annual review of cell and developmental biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jin Meng *Research Division, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-1347-9730
Ling Fu *State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Keke LiuState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Caiping TianState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Ziyun WuResearch Division, Joslin Diabetes Center, Boston, MA, USA.
Youngeun JungDepartment of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
Renan B FerreiraDepartment of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.ORCID 0000-0001-5205-659X
Kate S CarrollDepartment of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.ORCID 0000-0002-7624-9617
T Keith BlackwellResearch Division, Joslin Diabetes Center, Boston, MA, USA. keith.blackwell@joslin.harvard.edu.
Jing YangState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China. yangjing54@hotmail.com.ORCID 0000-0001-8486-273X
Joslin Diabetes Center · USScripps Research Institute · USBeijing Proteome Research Center · CNQingdao University · CN

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Sulfur Metabolism in Human PathogensR01GM087638 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARROLL, KATE SUZANNE · 2009 to 2025
$5.0M
Signaling mechanisms that detect stress and maintain homeostasis - Research Supplement to Promote Diversity in Health-Related ResearchR35GM122610 · NIGMS · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 2017 to 2025
$4.7M
Probing the role of cysteine sulfenylation in cell signalingR01GM102187 · NIGMS · UNIVERSITY OF FLORIDA · PI Kate Suzanne Carroll · 2012 to 2026
$4.6M
Redox Modification and Targeting of Mutant KRas in CancerR01CA227849 · NCI · UNIVERSITY OF FLORIDA · PI CARROLL, KATE SUZANNE · 2018 to 2021
$1.7M
NCI NIH HHS R01 CA227849NIDDK NIH HHS P30 DK036836NIGMS NIH HHS R01 GM087638NIGMS NIH HHS R01 GM102187NIGMS NIH HHS R35 GM122610NIH HHS P40 OD010440
6 · The paper itself

Abstract

Post-translational changes in the redox state of cysteine residues can rapidly and reversibly alter protein functions, thereby modulating biological processes. The nematode C. elegans is an ideal model organism for studying cysteine-mediated redox signaling at a network level. Here we present a comprehensive, quantitative, and site-specific profile of the intrinsic reactivity of the cysteinome in wild-type C. elegans. We also describe a global characterization of the C. elegans redoxome in which we measured changes in three major cysteine redox forms after H

Indexed as

AnimalsAntioxidantsCaenorhabditis elegansCaenorhabditis elegans ProteinsCysteineHydrogen PeroxideMAP Kinase Kinase 4Mitogen-Activated Protein KinasesMutationOxidation-Reductionp38 Mitogen-Activated Protein KinasesProteomicsSignal TransductionTranscription FactorsAntioxidantsCaenorhabditis elegans ProteinsCysteineDAF-19 protein, C elegansHydrogen PeroxideMAP Kinase Kinase 4Mitogen-Activated Protein Kinasesp38 Mitogen-Activated Protein KinasesPmk-1 protein, C eleganssek-1 protein, C elegansTranscription Factors

Identifiers

PMID33658510
PMCPMC7930113
OpenAlexW3135397144

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.