ArticleProceedings of the National Academy of Sciences of the United States of America2021
Excitatory cholecystokinin neurons of the midbrain integrate diverse temporal responses and drive auditory thalamic subdomains.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Molecular and cell type-specific determinants of inferior colliculus development and auditory function.bioRxiv : the preprint server for biology · 2026Article
- Molecular taxonomy and spatial organization define neuronal subtypes in the mouse inferior colliculus.iScience · 2026Article
- Ultrastructural characterization of neuropeptide Y synapses in the central inferior colliculus of the Fischer Brown Norway rat.Neuropeptides · 2025Article
- Age-related differences in GABAergic synapses across the central inferior colliculus in the Fischer Brown Norway rat.Neurobiology of aging · 2025Article
- Lineage-tracing reveals an expanded population of NPY neurons in the inferior colliculus.Journal of neurophysiology · 2024Article
- The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Lineage-tracing reveals an expanded population of NPY neurons in the inferior colliculus.bioRxiv : the preprint server for biology · 2024Article
- Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Identifying neuron types and circuit mechanisms in the auditory midbrain.Hearing research · 2024Review
- Neuropeptide Y Signaling Regulates Recurrent Excitation in the Auditory Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Organization of orbitofrontal-auditory pathways in the Mongolian gerbil.The Journal of comparative neurology · 2023Article
- Neuropeptide Y signaling regulates recurrent excitation in the auditory midbrain.bioRxiv : the preprint server for biology · 2023Article
- Article
- Long-Duration Sound-Induced Facilitation Changes Population Activity in the Inferior Colliculus.Frontiers in systems neuroscience · 2022Article
- Juxtacellular Labeling of Stellate, Disk and Basket Neurons in the Central Nucleus of the Guinea Pig Inferior Colliculus.Frontiers in neural circuits · 2021Article
- αFrontiers in neural circuits · 2021Article
- Targeting Subsets of Mammalian Neurons.Neuroscience insights · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
The central nucleus of the inferior colliculus (ICC) integrates information about different features of sound and then distributes this information to thalamocortical circuits. However, the lack of clear definitions of circuit elements in the ICC has limited our understanding of the nature of these circuit transformations. Here, we combine virus-based genetic access with electrophysiological and optogenetic approaches to identify a large family of excitatory, cholecystokinin-expressing thalamic projection neurons in the ICC of the Mongolian gerbil. We show that these neurons form a distinct cell type, displaying uniform morphology and intrinsic firing features, and provide powerful, spatially restricted excitation exclusively to the ventral auditory thalamus. In vivo, these neurons consistently exhibit V-shaped receptive field properties but strikingly diverse temporal responses to sound. Our results indicate that temporal response diversity is maintained within this population of otherwise uniform cells in the ICC and then relayed to cortex through spatially restricted thalamic subdomains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.