ArticleScience translational medicine2021
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 215 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 4 pooled it
21.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
215 citing papers in PubMed, 4 syntheses or guidelines pooled it, 304 citations in OpenAlex.
- Pooled it
- Human induced pluripotent stem cell models for Alzheimer's disease research: a bibliometric analysis.Frontiers in human neuroscience · 2025Pooled it
- Potential neuroprotective effects of fermented foods and beverages in old age: a systematic review.Frontiers in nutrition · 2023Pooled it
- Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites.Frontiers in neuroscience · 2022Pooled it
- Unveiling the pathogenesis and therapeutic strategies of Alzheimer's disease through cuproptosis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains.Cell stem cell · 2026Article
- Cyanobacteria-derived near-infrared autofluorescent exosomes enabling synergistic brain lesion imaging and neuroprotection.Bioactive materials · 2026Article
- APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics.Nature communications · 2026Article
- Review
- Review
- Recent advances in Alzheimer's disease: From molecular mechanisms to therapeutic strategies.Cell · 2026Review
- Changes in DNA methylation-based aging predicts brain damage and dementia and reflects life-course cardiovascular risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Lipid Metabolism Reprogramming in the Aging Brain: Glial-Mediated Pathogenic Mechanisms and Translational Strategies in Neurodegeneration.International journal of molecular sciences · 2026Review
- APOE4 Drives Uniquely Dysfunctional Human Microglial States in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2026Article
- Astrocytic ACSBG1 depletion improves lipid-cytokine signaling and attenuates α-Synuclein pathology in a Parkinson's disease mouse model.bioRxiv : the preprint server for biology · 2026Article
- HDL-mimetic peptide treatment reverses APOE4-induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A lifespan staging model of basal forebrain cholinergic vulnerability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Predicting late radiation-associated neurocognitive and endocrine toxicity in patients with brain tumors.Journal of neuro-oncology · 2026Article
- Article
- Genome-scale metabolic modeling uncovers cell-type specific signatures associated with APOE variants.iScience · 2026Article
155 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 7 institutions in 1 country.
Grzegorz SienskiWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0002-2730-7710
Priyanka NarayanWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0002-9328-4959
Julia Maeve BonnerWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0003-3551-9972
Nora KoryWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0001-5307-9021
Sebastian BolandDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-6694-2039
Aleksandra A ArczewskaDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
William T RalveniusPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.ORCID 0000-0002-0408-3443
Leyla AkayPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.ORCID 0000-0002-5944-2466
Elana LockshinPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.ORCID 0000-0001-5808-7995
Liang HeDuke University, Durham, NC 27708, USA.
Blerta MiloPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
Agnese GraziosiPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.ORCID 0000-0002-4992-7902
Valeriya BaruWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0001-8518-9313
Caroline A LewisWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0003-1787-5084
Manolis KellisBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.ORCID 0000-0001-7113-9630
David M SabatiniWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0002-1446-7256
Li-Huei TsaiPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA. lhtsai@mit.edu.ORCID 0000-0003-1262-0592
Susan LindquistWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
McGovern Institute for Brain Research · USWhitehead Institute for Biomedical Research · USBroad Institute · USHarvard University · USDuke University · USHoward Hughes Medical Institute · USNational Institutes of Health · US
Funding
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Teresa Gomez-Isla · 2019 to 2026
$36.5MInvestigating the molecular basis of risk and resilience to Alzheimer's diseaseZIADK075158 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI NARAYAN, PRIYANKA · 2021 to 2025
$11.4MEpigenomic, transcriptional and cellular dissection of Alzheimer's variantsR01AG058002 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HYMAN, BRADLEY T., JAENISCH, RUDOLF · 2017 to 2021
$7.9MRegulation of the mTOR Pathway By NutrientsR01CA103866 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2004 to 2021
$7.0MElucidating the Molecular Mechanisms of Neuropsychiatric Symptoms in Alzheimer's DiseaseR01AG062335 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS, TSAI, LI-HUEI · 2018 to 2022
$6.5MSingle-cell transcriptional and epigenomic dissection of Alzheimer's Disease and Related DementiasU01NS110453 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS, TSAI, LI-HUEI · 2018 to 2020
$4.0MDissection of endosomal trafficking mechanisms in Alzheimer's DiseaseRF1AG062377 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSAI, LI-HUEI · 2018 to 2018
$3.6MAlzheimer's Disease Risk Genes in Human Microglia and Neurons Derived from iPSCsRF1AG048029 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TSAI, LI-HUEI · 2014 to 2014
$2.1MDeciphering cell-type specific mechanisms of APOE4 in Alzheimer's diseaseK99AG055697 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NARAYAN, PRIYANKA · 2017 to 2018
$230kNCI NIH HHS R01 CA103866NIA NIH HHS K99 AG055697NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG058002NIA NIH HHS R01 AG062335NIA NIH HHS RF1 AG048029NIA NIH HHS RF1 AG062377NINDS NIH HHS U01 NS110453
Abstract
The
Indexed as
Alzheimer DiseaseInduced Pluripotent Stem CellsApolipoprotein E3Apolipoprotein E4Apolipoproteins EHomeostasisHumansNeurogliaApolipoprotein E3Apolipoprotein E4Apolipoproteins E
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.