Evidence map›Paper›PMID 33658338›Full record

ArticleJournal of virology2021

Virion structure and

Liya Mukhamedova, Tibor Füzik, Jiří Nováček, Dominik Hrebík, Antonín Přidal, Gerardo A Marti, Diego M A Guérin, Pavel Plevka

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Liya MukhamedovaStructural Virology Group, Central European Institute of Technology, Masaryk University, Kamenice 753/5, 62500 Brno, Czech Republic.
Tibor FüzikStructural Virology Group, Central European Institute of Technology, Masaryk University, Kamenice 753/5, 62500 Brno, Czech Republic.
Jiří NováčekStructural Virology Group, Central European Institute of Technology, Masaryk University, Kamenice 753/5, 62500 Brno, Czech Republic.
Dominik HrebíkStructural Virology Group, Central European Institute of Technology, Masaryk University, Kamenice 753/5, 62500 Brno, Czech Republic.
Antonín PřidalDepartment of Zoology, Fishery, Hydrobiology, and Apidology, Faculty of Agronomy, Mendel University in Brno, Zemědělská 1/1665, 613 00 Brno, Czech Republic.
Gerardo A MartiCentro de Estudios Parasitológicos y de Vectores (CEPAVE-CCT-La Plata-CONICET-UNLP), Boulevard 120 s/n e/60 y 64, 1900 La Plata, Argentina.
Diego M A GuérinDepartment of Biochemistry and Molecular Biology, University of the Basque Country (EHU), and Instituto Biofisika (CSIC-UPV/EHU). B° Sarriena S/N, 48940 Leioa, Vizcaya, Spain.
Pavel PlevkaStructural Virology Group, Central European Institute of Technology, Masaryk University, Kamenice 753/5, 62500 Brno, Czech Republic pavel.plevka@ceitec.muni.cz.ORCID https://orcid.org/0000-0003-4215-3315
Central European Institute of Technology · CZConsejo Nacional de Investigaciones Científicas y Técnicas · ARMendel University in Brno · CZUniversity of the Basque Country · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections of Kashmir bee virus (KBV) are lethal for honeybees and have been associated with colony collapse disorder. KBV and closely related viruses contribute to the ongoing decline in the number of honeybee colonies in North America, Europe, Australia, and other parts of the world. Despite the economic and ecological impact of KBV, its structure and infection process remain unknown. Here we present the structure of the virion of KBV determined to a resolution of 2.8 Å. We show that the exposure of KBV to acidic pH induces a reduction in inter-pentamer contacts within capsids and the reorganization of its RNA genome from a uniform distribution to regions of high and low density. Capsids of KBV crack into pieces at acidic pH, resulting in the formation of open particles lacking pentamers of capsid proteins. The large openings of capsids enable the rapid release of genomes and thus limit the probability of their degradation by RNases. The opening of capsids may be a shared mechanism for the genome release of viruses from the family

Identifiers

PMID33658338
PMCPMC8139710
OpenAlexW3134393899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.