ArticleProceedings of the National Academy of Sciences of the United States of America2021
Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers.
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181citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
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Who cites it
181 citing papers in PubMed, 239 citations in OpenAlex.
- Large-scale human genomic resources drive innovations toward forensic intelligent source attribution and precision identification.International journal of legal medicine · 2026Review
- Human infection with pseudorabies virus: review of evidence, risk assessment, and future directions.Journal of virology · 2026Review
- SARS-CoV-2 virus infection ofbioRxiv : the preprint server for biology · 2026Article
- Species- and variant-specific ACE2 compatibility shapes SARS-CoV-2 spillover potential in North American cervids.Nature communications · 2026Article
- Systematic multi-reference vertebrate ACE2 sequence similarity analysis predicts species susceptibility to SARS-related sarbecoviruses.Scientific reports · 2026Article
- Glucocorticoids suppress early lung inflammation and impair control of SARS-CoV-2 in non-human primates.PloS one · 2026Article
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- The coronaviral landscape across diverse mammalian species in the Northeastern United States.Scientific reports · 2025Article
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- Metaproteomics reveals age-specific alterations of gut microbiome in hamsters with SARS-CoV-2 infection.Gut microbes · 2025Article
- From zoonotic spillover to endemicity: the broad determinants of human coronavirus tropism.mBio · 2025Review
- SARS-CoV-2 Evolution in Humans Enables Its Transmission to Nonhuman Primates.Molecular biology and evolution · 2025Article
- Engineering virus-like particles for safe and versatile modeling of SARS-CoV-2 host interaction and immune escape.Communications biology · 2025Article
- CX1/BtSY2 and BANAL-20-52 exhibit broader receptor binding and higher affinities to multiple animal ACE2 orthologs than SARS-CoV-2 prototype.Journal of virology · 2025Article
- Critical amino acid residues in human ACE2 for SARS-CoV-2 spike protein binding and virus entry.Microbiology spectrum · 2025Article
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- Structures and receptor binding activities of merbecovirus spike proteins reveal key signatures for human DPP4 adaptation.Science advances · 2025Article
- SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals.Cell reports · 2025Article
- Molecular mechanisms of RaTG13 and SARS-CoV-2 RBD bound to Rhinolophus affinis bat ACE2.Protein science : a publication of the Protein Society · 2025Article
- Distribution of aminopeptidase N coronavirus receptors in the respiratory and digestive tracts of domestic and wild artiodactyls and carnivores.The Journal of general virology · 2025Article
121 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 4 institutions in 1 country.
Yinghui LiuCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Gaowei HuKey Laboratory of Medical Molecular Virology, Biosafety Level 3 Laboratory, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Yuyan WangKey Laboratory of Medical Molecular Virology, Biosafety Level 3 Laboratory, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Wenlin RenCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.ORCID https://orcid.org/0000-0002-7290-0935
Xiaomin ZhaoCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Fansen JiCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Yunkai ZhuKey Laboratory of Medical Molecular Virology, Biosafety Level 3 Laboratory, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Fei FengKey Laboratory of Medical Molecular Virology, Biosafety Level 3 Laboratory, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Mingli GongCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Xiaohui JuCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.ORCID https://orcid.org/0000-0002-9552-0222
Yuanfei ZhuKey Laboratory of Medical Molecular Virology, Biosafety Level 3 Laboratory, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Xia CaiKey Laboratory of Medical Molecular Virology, Biosafety Level 3 Laboratory, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Jun LanSchool of Life Sciences, Tsinghua University, 100084 Beijing, China.
Jianying GuoCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.ORCID https://orcid.org/0000-0003-4136-0857
Min XieCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Lin DongCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Zihui ZhuCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Jie NaCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Jianping WuKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 310024 Hangzhou, China.ORCID https://orcid.org/0000-0001-9869-7691
Xun LanCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Youhua XieKey Laboratory of Medical Molecular Virology, Biosafety Level 3 Laboratory, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Xinquan WangSchool of Life Sciences, Tsinghua University, 100084 Beijing, China.
Zhenghong YuanKey Laboratory of Medical Molecular Virology, Biosafety Level 3 Laboratory, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China; zhyuan@shmu.edu.cn rong_zhang@fudan.edu.cn qding@tsinghua.edu.cn.
Rong ZhangKey Laboratory of Medical Molecular Virology, Biosafety Level 3 Laboratory, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China; zhyuan@shmu.edu.cn rong_zhang@fudan.edu.cn qding@tsinghua.edu.cn.
Qiang DingCenter for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China; zhyuan@shmu.edu.cn rong_zhang@fudan.edu.cn qding@tsinghua.edu.cn.
Tsinghua University · CNShanghai Medical College of Fudan University · CNBeijing Advanced Sciences and Innovation Center · CNWestlake University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pandemic of COVID-19, caused by SARS-CoV-2, is a major global health threat. Epidemiological studies suggest that bats (
Indexed as
Angiotensin-Converting Enzyme 2AnimalsCOVID-19Host SpecificityHumansPandemicsPeptidyl-Dipeptidase APhylogenyProtein BindingReceptors, VirusSARS-CoV-2Spike Glycoprotein, CoronavirusViral TropismViral ZoonosesVirus AttachmentVirus InternalizationAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase AReceptors, VirusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ACE2COVID-19host rangeintermediate hostSARS-CoV-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.