Evidence map›Paper›PMID 33658306›Full record

ArticleeNeuro

Interneuron Dysfunction in a New Mouse Model of SCN1A GEFS.

Antara Das, Bingyao Zhu, Yunyao Xie, Lisha Zeng, An T Pham, Jonathan C Neumann, Olga Safrina, Daniel R Benavides, Grant R MacGregor, Soleil S Schutte and 2 more

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Prime editing of a pathogenicScience translational medicine · 2026
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  14. Dravet VariantFrontiers in cellular neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Antara DasDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697.ORCID 0000-0002-9593-8856
Bingyao ZhuDepartment of Anatomy and Neurobiology, University of California, Irvine, CA 92697.
Yunyao XieDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697.ORCID 0000-0003-0247-1693
Lisha ZengDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697.ORCID 0000-0001-7758-5156
An T PhamDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697.
Jonathan C NeumannTransgenic Mouse Facility, Office of Research, University of California, Irvine, CA 92697.
Olga SafrinaDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697.
Daniel R BenavidesDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697.
Grant R MacGregorDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697.ORCID 0000-0001-7598-9501
Soleil S SchutteDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697.
Robert F HuntDepartment of Anatomy and Neurobiology, University of California, Irvine, CA 92697 robert.hunt@uci.edu dkodowd@uci.edu.
Diane K O'DowdDepartment of Developmental and Cell Biology, University of California, Irvine, CA 92697 robert.hunt@uci.edu dkodowd@uci.edu.
University of California, Irvine · USUniversity of California System · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Rewiring the Injured Brain with GABA ProgenitorsR01NS096012 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUNT, ROBERT F · 2016 to 2025
$3.8M
NCI NIH HHS P30 CA062203NINDS NIH HHS R01 NS096012
6 · The paper itself

Abstract

Advances in genome sequencing have identified over 1300 mutations in the

Indexed as

NAV1.1 Voltage-Gated Sodium ChannelSeizures, FebrileAnimalsInterneuronsMiceMice, Inbred C57BLMutationSeizuresNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mouseCRISPR/Cas9epilepsyGEFS+parvalbumin interneuronsSCN1Aseizures

Identifiers

PMID33658306
PMCPMC8174035
OpenAlexW3135636551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.