Evidence map›Paper›PMID 33658297›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.

Brigette Boast, Lisa A Miosge, Hye Sun Kuehn, Vicky Cho, Vicki Athanasopoulos, Hayley A McNamara, Yovina Sontani, Yan Mei, Debbie Howard, Henry J Sutton and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Brigette BoastDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.ORCID 0000-0003-0089-7551
Lisa A MiosgeDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Hye Sun KuehnImmunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD 20892.
Vicky ChoDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.ORCID 0000-0001-9039-9876
Vicki AthanasopoulosDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.ORCID 0000-0002-5764-5948
Hayley A McNamaraDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.ORCID 0000-0001-6347-6215
Yovina SontaniDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.ORCID 0000-0001-9553-5304
Yan MeiDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Debbie HowardDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Henry J SuttonDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.ORCID 0000-0002-6472-7116
Sofia A OmariDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Zhijia YuDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.ORCID 0000-0002-4763-4698
Mariam NasreenAustralian Phenomics Facility, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia; and.ORCID 0000-0001-9111-9717
T Daniel AndrewsDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Ian A CockburnDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.ORCID 0000-0001-8220-9294
Christopher C GoodnowImmunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.ORCID 0000-0001-5296-6155
Sergio D RosenzweigImmunology Service, Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD 20892.
Anselm EndersDepartment of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia; anselm.enders@anu.edu.au.ORCID 0000-0001-5933-6463
Australian National University · AUNational Institutes of Health Clinical Center · USGarvan Institute of Medical Research · AU

Funding

Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ULEVITCH, RICHARD J · 2012 to 2021
$49.1M
Genes for Tolerance and Immunity ConsortiumR01AI052127 · NIAID · AUSTRALIAN NATIONAL UNIVERSITY · PI GOODNOW, CHRISTOPHER CARL · 2002 to 2006
$6.3M
NIAID NIH HHS R01 AI052127NIAID NIH HHS U19 AI100627
6 · The paper itself

Abstract

IKZF1 (IKAROS) is essential for normal lymphopoiesis in both humans and mice. Previous

Indexed as

AnimalsAntibody FormationB-LymphocytesCommon Variable ImmunodeficiencyHaploinsufficiencyHeat Shock Transcription FactorsHEK293 CellsHumansIkaros Transcription FactorImmunoglobulinsMiceMice, Inbred C57BLMice, Mutant StrainsNIH 3T3 CellsPoint MutationHeat Shock Transcription FactorsHsf1 protein, mouseIkaros Transcription FactorImmunoglobulins

Identifiers

PMID33658297
PMCPMC7987828
OpenAlexW3134702443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.