Evidence map›Paper›PMID 33658275›Full record

ArticlemSphere2021

A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630Δ

Daniel Troitzsch, Hao Zhang, Silvia Dittmann, Dorothee Düsterhöft, Timon Alexander Möller, Annika-Marisa Michel, Lothar Jänsch, Katharina Riedel, José Manuel Borrero-de Acuña, Dieter Jahn and 1 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. The critical role ofApplied and environmental microbiology · 2026
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  5. Impacts ofJournal of bacteriology · 2025
    Article
  6. Article
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  8. Journal of bacteriology · 2024
    Article
  9. Characterizing the flavodoxin landscape inMicrobiology spectrum · 2024
    Article
  10. Article
  11. Microbial genomics · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Daniel TroitzschDepartment of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany.
Hao ZhangInstitute of Microbiology, Technical University of Braunschweig, Braunschweig, Germany.
Silvia DittmannDepartment of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany.
Dorothee DüsterhöftDepartment of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany.
Timon Alexander MöllerDepartment of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany.
Annika-Marisa MichelInstitute of Microbiology, Technical University of Braunschweig, Braunschweig, Germany.
Lothar JänschHelmholtz Center for Infection Research, Braunschweig, Germany.
Katharina RiedelDepartment of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany.
José Manuel Borrero-de AcuñaInstitute of Microbiology, Technical University of Braunschweig, Braunschweig, Germany.
Dieter JahnInstitute of Microbiology, Technical University of Braunschweig, Braunschweig, Germany.ORCID 0000-0002-4064-9205
Susanne SieversDepartment of Microbial Physiology and Molecular Biology, Institute of Microbiology, University of Greifswald, Greifswald, Germany susanne.sievers@uni-greifswald.de.ORCID 0000-0002-5457-2552
Universität Greifswald · DETechnische Universität Braunschweig · DEHelmholtz Centre for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human pathogen

Indexed as

Point MutationClostridioides difficileDNA, BacterialGene Expression Regulation, BacterialOxidative StressRepressor ProteinsTranscription FactorsVirulenceDNA, BacterialRepressor ProteinsTranscription FactorsClostridioides difficileconstitutive expressionDNA bindingoxidative stress responsePerRrubrerythrinsingle nucleotide polymorphismSNPtranscriptional repressor

Identifiers

PMID33658275
PMCPMC8546684
OpenAlexW3135842290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.