Evidence map›Paper›PMID 33658226›Full record

ArticleDevelopment (Cambridge, England)2021

Groucho co-repressor proteins regulate β cell development and proliferation by repressing

Alexandra Theis, Ruth A Singer, Diana Garofalo, Alexander Paul, Anila Narayana, Lori Sussel

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexandra TheisDepartment of Pediatrics and Cell & Developmental Biology, Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Ruth A SingerDepartment of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
Diana GarofaloDepartment of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
Alexander PaulDepartment of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
Anila NarayanaDepartment of Pediatrics and Cell & Developmental Biology, Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Lori SusselDepartment of Pediatrics and Cell & Developmental Biology, Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA lori.sussel@ucdenver.edu.ORCID 0000-0003-4672-7304
Columbia University Irving Medical Center · USUniversity of Colorado Anschutz Medical Campus · US

Funding

University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANE E REUSCH · 2020 to 2026
$10.8M
Regulation of Pancreatic Islet Cell FateR01DK082590 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2009 to 2026
$7.3M
The role of long noncoding RNAs in regulating pancreas development and functionF31DK107028 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SINGER, RUTH A · 2015 to 2018
$132k
Groucho co-repressors in the regulation of pancreatic islet developmentF31DK122634 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI THEIS, ALEXANDRA · 2019 to 2021
$106k
NIDDK NIH HHS F31 DK107028NIDDK NIH HHS F31 DK122634NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK082590
6 · The paper itself

Abstract

Groucho-related genes (GRGs) are transcriptional co-repressors that are crucial for many developmental processes. Several essential pancreatic transcription factors are capable of interacting with GRGs; however, the

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationCell ProliferationCo-Repressor ProteinsGene Expression Regulation, DevelopmentalHepatocyte Nuclear Factor 3-alphaInsulin-Secreting CellsLiverMiceMutationOrganogenesisPancreasRepressor ProteinsBasic Helix-Loop-Helix ProteinsCo-Repressor ProteinsFoxa1 protein, mouseHepatocyte Nuclear Factor 3-alphaNeurod1 protein, mouseRepressor ProteinsTle3 protein, mouseTle4 protein, mouseFoxa1Groucho/TLE co-repressorMousePancreas developmentβ cells

Identifiers

PMID33658226
PMCPMC8015241
OpenAlexW3135043484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.