Evidence map›Paper›PMID 33658225›Full record

ArticleDevelopment (Cambridge, England)2021

Blocking estrogen-induced AMH expression is crucial for normal follicle formation.

Ren Tanimoto, Kiyono Sekii, Kanako Morohaku, Jianzhen Li, David Pépin, Yayoi Obata

Open access · hybridAbstract read
In one paragraph

Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Building a resilient ovarian reserve: Early soma-oocyte interactions.Current topics in developmental biology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ren TanimotoDepartment of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.ORCID 0000-0001-5568-6044
Kiyono SekiiDepartment of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
Kanako MorohakuDepartment of Agriculture and Life Sciences, Shinshu University 8304 Minami-Minowa-mura Kamiina-gun, Nagano 399-4598, Japan.
Jianzhen LiDepartment of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
David PépinDepartment of Surgery, Harvard Medical School, Boston, MA 02115, USA.
Yayoi ObataDepartment of Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan y1obata@nodai.ac.jp.ORCID 0000-0001-7445-7650
Tokyo University of Agriculture · JPHarvard University · USShinshu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In mammals, primordial follicles assembled in fetuses or during infancy constitute the oocyte resources for life. Exposure to 17beta-estradiol and phytogenic or endocrine-disrupting chemicals during pregnancy and/or the perinatal period leads to the failure of normal follicle formation. However, the mechanisms underlying estrogen-mediated abnormal follicle formation and physiological follicle formation in the presence of endogenous natural estrogen are not well understood. Here, we reveal that estrogen receptor 1, activated by estrogen, binds to the 5' region of the anti-Mullerian hormone (

Indexed as

alpha-FetoproteinsAnimalsAnti-Mullerian HormoneEndocrine DisruptorsEstradiolEstrogen Receptor alphaEstrogensFemaleHumansMiceOocytesOvarian FollicleTranscription, Geneticalpha-FetoproteinsAnti-Mullerian HormoneEndocrine DisruptorsEstradiolEstrogen Receptor alphaEstrogensAlpha-fetoproteinAMHEstrogenEstrogen receptorFollicle formationMouse

Identifiers

PMID33658225
PMCPMC7990856
OpenAlexW3135093906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.