Evidence map›Paper›PMID 33658223›Full record

ArticleDevelopment (Cambridge, England)2021

Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives.

Matthew Wind, Antigoni Gogolou, Ichcha Manipur, Ilaria Granata, Larissa Butler, Peter W Andrews, Ivana Barbaric, Ke Ning, Mario R Guarracino, Marysia Placzek and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Matthew WindCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.
Antigoni GogolouCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.ORCID 0000-0002-3581-2426
Ichcha ManipurComputational and Data Science Laboratory, High Performance Computing and Networking Institute, National Research Council of Italy, Napoli 80131, Italy.ORCID 0000-0001-5348-8378
Ilaria GranataComputational and Data Science Laboratory, High Performance Computing and Networking Institute, National Research Council of Italy, Napoli 80131, Italy.ORCID 0000-0002-3450-4667
Larissa ButlerCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.
Peter W AndrewsCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.
Ivana BarbaricCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK.ORCID 0000-0003-3120-9563
Ke NingDepartment of Neuroscience, Neuroscience Institute, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.ORCID 0000-0002-0771-1134
Mario R GuarracinoUniversity of Cassino and Southern Lazio, Cassino 03043, Italy.
Marysia PlaczekDepartment of Biomedical Science and Bateson Centre, University of Sheffield, Sheffield S10 2TN, UK.ORCID 0000-0002-4106-9229
Anestis TsakiridisCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield S10 2TN, UK a.tsakiridis@sheffield.ac.uk.ORCID 0000-0002-2184-2990
University of Sheffield · GBInstitute for High Performance Computing and Networking · ITUniversità degli studi di Cassino e del Lazio Meridionale · IT

Funding

Biotechnology and Biological Sciences Research Council BB/P000444/1Medical Research Council MR/M010864/1Medical Research Council MR/R015724/1Medical Research Council MR/V002163/1Wellcome TrustWellcome Trust 212247/Z/18/Z
6 · The paper itself

Abstract

The anteroposterior axial identity of motor neurons (MNs) determines their functionality and vulnerability to neurodegeneration. Thus, it is a crucial parameter in the design of strategies aiming to produce MNs from human pluripotent stem cells (hPSCs) for regenerative medicine/disease modelling applications. However, the

Indexed as

AnimalsBody PatterningBone Morphogenetic ProteinsCell DifferentiationCell LineageChick EmbryoFibroblast Growth FactorsGene Expression Regulation, DevelopmentalHumansMesodermMotor NeuronsNeural Stem CellsPluripotent Stem CellsSignal TransductionSpinal CordTransforming Growth Factor betaBone Morphogenetic ProteinsFibroblast Growth FactorsTransforming Growth Factor betaWnt ProteinsHuman pluripotent stem cellsIn vitro differentiationMotor neuronsNeuromesodermal progenitorsRegional identitySpinal cord

Identifiers

PMID33658223
PMCPMC8015249
OpenAlexW3134465191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.