ArticleScience advances2021
A single-molecule electrical approach for amino acid detection and chirality recognition.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 72 citations in OpenAlex.
- Label-Free Optical Differentiation of Single Diffusing Amino Acids at Picomolar Concentrations.Research square · 2026Article
- Rapid enantioselective fluorescence recognition and chiral separation of free amino acids.Nature communications · 2026Article
- Catechin-Targeted Nano-Enhanced Colorimetric Sensor Array Based on Quantum Dots-Nano Porphyrin for Precise Analysis of Xihu Longjing from Adjacent Origins.Foods (Basel, Switzerland) · 2025Article
- A homochiral covalent organic framework membrane for the enantioseparation and fractionation of amino acids.Nature communications · 2025Article
- Pioneering Role of Nanopore Single-Molecule Sensing in Environmental and Food Surveillance.Biosensors · 2025Review
- Single-Molecule Electrical Profiling of Peptides and Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Review
- Real-time detection of 20 amino acids and discrimination of pathologically relevant peptides with functionalized nanopore.Nature methods · 2024Article
- Recent Progress in Detecting Enantiomers in Food.Molecules (Basel, Switzerland) · 2024Review
- Controlling piezoresistance in single molecules through the isomerisation of bullvalenes.Nature communications · 2023Article
- Precise Detection, Control and Synthesis of Chiral Compounds at Single-Molecule Resolution.Nano-micro letters · 2023Article
- Construction of chiral capillary electrochromatography microsystems based on Aspergillus sp. CM96.Mikrochimica acta · 2023Article
- Beyond Stereoisomeric Effects: Exploring the Importance of Intermolecular Electron Spin Interactions in Biorecognition.The journal of physical chemistry letters · 2023Article
- Graphene-molecule-graphene single-molecule junctions to detect electronic reactions at the molecular scale.Nature protocols · 2023Review
- Advances in single-molecule junctions as tools for chemical and biochemical analysis.Nature chemistry · 2023Review
- Single-Molecule Peptide Identification Using Fluorescence Blinking Fingerprints.Journal of the American Chemical Society · 2023Article
- Measuring conductance switching in single proteins using quantum tunneling.Science advances · 2022Article
- A Review of Sensors and Biosensors Modified with Conducting Polymers and Molecularly Imprinted Polymers Used in Electrochemical Detection of Amino Acids: Phenylalanine, Tyrosine, and Tryptophan.International journal of molecular sciences · 2022Review
- Silicon - single molecule - silicon circuits.Chemical science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the ultimate goals of analytic chemistry is to efficiently discriminate between amino acids. Here we demonstrate this ability using a single-molecule electrical methodology based on molecular nanocircuits formed from stable graphene-molecule-graphene single-molecule junctions. These molecular junctions are fabricated by covalently bonding a molecular machine featuring a permethylated-β-cyclodextrin between a pair of graphene point contacts. Using pH to vary the type and charge of the amino acids, we find distinct multimodal current fluctuations originating from the different host-guest interactions, consistent with theoretical calculations. These conductance data produce characteristic dwell times and shuttling rates for each amino acid, and allow accurate, statistical real-time, in situ measurements. Testing four amino acids and their enantiomers shows the ability to distinguish between them within a few microseconds, thus paving a facile and precise way to amino acid identification and even single-molecule protein sequencing.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.