ArticleScience advances2021
Modulation of intercolumnar synchronization by endogenous electric fields in cerebral cortex.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Gap junctional and ephaptic coupling in cardiac electrical propagation: homocellular and heterocellular perspectives.The Journal of physiology · 2026Review
- Regular afferent activity and structural homogeneity gate ephaptic synchronization in the dorsal column.Frontiers in human neuroscience · 2026Article
- Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness.eLife · 2025Article
- Network Desynchronization with Sine Waves: from Synchrony to Asynchrony by Periodic Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- In vivo ephaptic coupling allows memory network formation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Improving Functional Abilities in Children and Adolescents with Autism Spectrum Disorder Using Non-Invasive REAC Neuro Psycho Physical Optimization Treatments: A PEDI-CAT Study.Journal of personalized medicine · 2023Article
- A microfluidic perspective on conventional in vitro transcranial direct current stimulation methods.Journal of neuroscience methods · 2023Review
- Visual cortical LFP in relation to the hippocampal theta rhythm in track running rats.Frontiers in cellular neuroscience · 2023Article
- Subthreshold Oscillating Waves in Neural Tissue Propagate by Volume Conduction and Generate Interference.Brain sciences · 2022Article
- Theta waves, neural spikes and seizures can propagate by ephaptic coupling in vivo.Experimental neurology · 2022Article
- Ephaptic entrainment in hybrid neuronal model.Scientific reports · 2022Article
- Controlling the local extracellular electric field can suppress the generation and propagation of seizures and spikes in the hippocampus.Brain stimulationArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons synaptically interacting in a conductive medium generate extracellular endogenous electric fields (EFs) that reciprocally affect membrane potential. Exogenous EFs modulate neuronal activity, and their clinical applications are being profusely explored. However, whether endogenous EFs contribute to network synchronization remains unclear. We analyzed spontaneously generated slow-wave activity in the cerebral cortex network in vitro, which allowed us to distinguish synaptic from nonsynaptic mechanisms of activity propagation and synchronization. Slow oscillations generated EFs that propagated independently of synaptic transmission. We demonstrate that cortical oscillations modulate spontaneous rhythmic activity of neighboring synaptically disconnected cortical columns if layers are aligned. We provide experimental evidence that these EF-mediated effects are compatible with electric dipoles. With a model of interacting dipoles, we reproduce the experimental measurements and predict that endogenous EF-mediated synchronizing effects should be relevant in the brain. Thus, experiments and models suggest that electric-dipole interactions contribute to synchronization of neighboring cortical columns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.