Evidence map›Paper›PMID 33658076›Full record

ArticleJournal of cheminformatics2021

Structure-based identification of dual ligands at the A

Leen Kalash, Ian Winfield, Dewi Safitri, Marcel Bermudez, Sabrina Carvalho, Robert Glen, Graham Ladds, Andreas Bender

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cheminformatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Leen Kalash *Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, CB21EW, Cambridge, UK.ORCID http://orcid.org/0000-0002-1751-6658
Ian Winfield *Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, CB21EW, Cambridge, UK.
Dewi Safitri *Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD, Cambridge, UK.ORCID https://orcid.org/0000-0003-2260-3892
Marcel BermudezCentre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, CB21EW, Cambridge, UK.ORCID https://orcid.org/0000-0002-7421-3282
Sabrina CarvalhoDepartment of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD, Cambridge, UK.
Robert GlenCentre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, CB21EW, Cambridge, UK.ORCID https://orcid.org/0000-0003-1759-2914
Graham LaddsDepartment of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD, Cambridge, UK. grl30@cam.ac.uk.ORCID https://orcid.org/0000-0001-7320-9612
Andreas BenderCentre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, CB21EW, Cambridge, UK. ab454@cam.ac.uk.
University of Cambridge · GBBandung Institute of Technology · IDGlaxoSmithKline (United Kingdom) · GB

Funding

European Research Council 336159
6 · The paper itself

Abstract

Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP, the A

Indexed as

A2ARAnti‐proliferativeDockingDual targetLung cancerMD simulationsNSCLCPDE10AStructure‐based designTriazoloquinazolinesVirtual screening

Identifiers

PMID33658076
PMCPMC7927403
OpenAlexW3135691966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.