SynthesisArteriosclerosis, thrombosis, and vascular biology2021
Plasma Protein Profile of Carotid Artery Atherosclerosis and Atherosclerotic Outcomes: Meta-Analyses and Mendelian Randomization Analyses.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Candidate Biomarkers Linking Periodontitis with Atherosclerotic and Related Cardiovascular Phenotypes: A Systematic Review Focused on Sex-Specific Evidence.International journal of molecular sciences · 2026Pooled it
- Prognostic effect of osteoprotegerin in patients with ischemic stroke: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Enhanced Prediction of Peripheral Artery Disease Using Plasma Proteomics Among Individuals Without Diabetes.Journal of the American Heart Association · 2026Article
- Proteomic pathways mediating low socioeconomic status and cardiovascular events in older adults in CHS and ARIC.Atherosclerosis · 2026Article
- Plasma proteomics and incident coronary heart disease.Communications medicine · 2026Article
- Plasma Protein Profile Associated With a Family History of Early-Onset Coronary Heart Disease.Circulation. Genomic and precision medicine · 2025Article
- Associations between carotid artery intima-media thickness, traditional risk factors and proteins.NPJ cardiovascular health · 2025Article
- Potential drug targets for peripheral artery disease identified through Mendelian randomization analysis.Thrombosis journal · 2025Article
- Plasma proteome and incident myocardial infarction: sex-specific differences.European heart journal · 2024Article
- Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank.Nature cardiovascular research · 2024Article
- Mendelian randomization reveals plasminogen as a common therapeutic target for myocardial infarction and atrial fibrillation.Journal of cardiovascular and thoracic research · 2024Article
- Plasma Proteomic Associations With Incident Ischemic Stroke in Older Adults: The Cardiovascular Health Study.Neurology · 2023Article
- Circulating proteins and peripheral artery disease risk: observational and Mendelian randomization analyses.European heart journal open · 2023Article
- Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation.Nature cardiovascular research · 2022Article
- Carpal Tunnel Syndrome and Ulnar Nerve Entrapment at the Elbow Are Not Associated With Plasma Levels of Caspase-3, Caspase-8 or HSP27.Frontiers in neuroscience · 2022Article
- Impaired sensitivity to thyroid hormones and carotid plaque in patients with coronary heart disease: A RCSCD-TCM study in China.Frontiers in endocrinology · 2022Article
- Large-Scale Plasma Protein Profiling of Incident Myocardial Infarction, Ischemic Stroke, and Heart Failure.Journal of the American Heart Association · 2021Article
- Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth Factors.Biomedicines · 2021Article
Corrections and comments
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Authors and funding
21 authors at 8 institutions in 6 countries.
Lars LindDepartment of Medical Sciences, Uppsala University, Sweden (L.L., J.S.).
Bruna GiganteUnit of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Sweden (B.G., A.H., A.M.).
Yan BornéDepartment of Clinical Sciences Malmö, Lund University, Sweden (Y.B., M.O.-M., J.N., O.M., G.E.).
Tobias FeldreichSchool of Health and Social Sciences, Dalarna University, Falun, Sweden (T.F., J.A.).
Jerzy LeppertCentre for Clinical Research, Uppsala University (J.L., P.H.), Västmanland County Hospital, Västerås, Sweden.
Pär HedbergCentre for Clinical Research, Uppsala University (J.L., P.H.), Västmanland County Hospital, Västerås, Sweden.
Carl Johan ÖstgrenDepartment of Health, Medicine and Caring Sciences, Linköping University, Sweden (C.J.O., F.H.N.).
Fredrik H NyströmDepartment of Health, Medicine and Caring Sciences, Linköping University, Sweden (C.J.O., F.H.N.).
Johan SundströmDepartment of Medical Sciences, Uppsala University, Sweden (L.L., J.S.).
Johan ÄrnlövSchool of Health and Social Sciences, Dalarna University, Falun, Sweden (T.F., J.A.).
Damiano BaldassarreDamiano Baldassarre, Department of Medical Biotechnology and Translational Medicine, Università di Milano (D.B.).
Elena TremoliCentro Cardiologico Monzino, IRCCS, Milan, Italy (D.B., E.T., F.V.).
Fabrizio VegliaCentro Cardiologico Monzino, IRCCS, Milan, Italy (D.B., E.T., F.V.).
Anders HamstenUnit of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Sweden (B.G., A.H., A.M.).
Christopher J O'DonnellDepartment of Health, Medicine and Caring Sciences, Linköping University, Sweden (C.J.O., F.H.N.).
Nora FranceschiniDepartment of Epidemiology, University of North Caroline, Capel Hill (N.F.).
Marju Orho-MelanderDepartment of Clinical Sciences Malmö, Lund University, Sweden (Y.B., M.O.-M., J.N., O.M., G.E.).
Jan NilssonDepartment of Clinical Sciences Malmö, Lund University, Sweden (Y.B., M.O.-M., J.N., O.M., G.E.).
Olle MelanderDepartment of Clinical Sciences Malmö, Lund University, Sweden (Y.B., M.O.-M., J.N., O.M., G.E.).
Gunnar EngströmDepartment of Clinical Sciences Malmö, Lund University, Sweden (Y.B., M.O.-M., J.N., O.M., G.E.).
Anders MälarstigUnit of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Sweden (B.G., A.H., A.M.).
Malmö University · SECentro Cardiologico Monzino · ITKarolinska Institutet · SELinköping University · SEDalarna University · SEUppsala University · SEUppsala University Hospital · SEUniversity of North Carolina System · US
Funding
Leveraging ancestry to map kidney lociR01MD012765 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2021
$3.6MGenetics of kidney disease in diverse populationsR01DK117445 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2018 to 2022
$2.7MTrans-ethnic meta-analysis of blood pressure in African and European ancestriesR21HL123677 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2014 to 2015
$242kNHLBI NIH HHS R21 HL123677NIDDK NIH HHS R01 DK117445NIMHD NIH HHS R01 MD012765
Abstract
[Figure: see text].
Indexed as
Genetic VariationProteomeAgedBiomarkersBlood ProteinsCarotid Artery DiseasesCarotid Intima-Media ThicknessFemaleHumansIncidenceMaleMatrix Metalloproteinase 12Mendelian Randomization AnalysisMiddle AgedPlaque, AtheroscleroticPrognosisBiomarkersBlood ProteinsMatrix Metalloproteinase 12MMP12 protein, humanProteomeatherosclerosiscarotid arteriesepidemiologyischemic strokemyocardial infarctionprotein
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.