Evidence map›Paper›PMID 33657648›Full record

ReviewAllergy2021

Allergenic components of the mRNA-1273 vaccine for COVID-19: Possible involvement of polyethylene glycol and IgG-mediated complement activation.

Ludger Klimek, Natalija Novak, Beatriz Cabanillas, Marek Jutel, Jean Bousquet, Cezmi A Akdis

Open access · bronzeAbstract readReview
In one paragraph

Review in Allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 3 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. The adverse reactions to vaccines practice parameter 10 years on-what have we learned?Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Guideline
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Materials today. Bio · 2025
    Review
  7. Review
  8. Article
  9. Advances and Strategies in Enhancing mRNA Cancer Vaccines.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
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  11. Review
  12. Article
  13. Review
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  16. Article
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  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Ludger KlimekCenter for Rhinology and Allergology, Wiesbaden, Germany.
Natalija NovakDepartment of Dermatology and Allergy, University Hospital, Bonn, Germany.
Beatriz CabanillasDepartment of Allergy, Research Institute Hospital 12 de Octubre, Madrid, Spain.
Marek JutelDepartment of Clinical Immunology, Wrocław Medical University, Poland, ALL-MED Medical research Institute, Wroclaw, Poland.
Jean BousquetComprehensive Allergy Center, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.ORCID 0000-0002-4061-4766
Cezmi A AkdisSwiss Institute of Allergy and Asthma Research (SIAF, University of Zurich, Davos, Switzerland.ORCID 0000-0001-8020-019X
Humboldt-Universität zu Berlin · DEResearch Institute Hospital 12 de Octubre · ESUniversity Hospital Bonn · DEUniversity of Zurich · CHWroclaw Medical University · PLZentrum für Rhinologie und Allergologie · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following the emergency use authorization of the mRNA-1273 vaccine on the 18

Indexed as

AnaphylaxisCOVID-192019-nCoV Vaccine mRNA-1273AllergensComplement ActivationCOVID-19 VaccinesHumansImmunoglobulin GPolyethylene GlycolsSARS-CoV-2United States2019-nCoV Vaccine mRNA-1273AllergensCOVID-19 VaccinesImmunoglobulin GPolyethylene GlycolsCOVIDSARS-CoVvaccines

Identifiers

PMID33657648
PMCPMC8013891
OpenAlexW3135561646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.