Evidence map›Paper›PMID 33657573›Full record

ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)2021

Extracorporeal Membrane Oxygenation for COVID-19: Updated 2021 Guidelines from the Extracorporeal Life Support Organization.

Jenelle Badulak, M Velia Antonini, Christine M Stead, Lara Shekerdemian, Lakshmi Raman, Matthew L Paden, Cara Agerstrand, Robert H Bartlett, Nicholas Barrett, Alain Combes and 12 more

Abstract read
In one paragraph

Article in ASAIO journal (American Society for Artificial Internal Organs : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

193 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Pooled it
  6. ECMO in COVID-19 Patients: A Systematic Review and Meta-analysis.Journal of cardiothoracic and vascular anesthesia · 2022
    Pooled it
  7. Pooled it
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  10. Pooled it
  11. Review
  12. Article
  13. Impact of preoperative venovenous extracorporeal membrane oxygenation bridging on postoperative acute kidney injury after lung transplantation.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026
    Article
  14. Observational
  15. ECMO use in infants with bronchopulmonary dysplasia: a literature review.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  16. Anticoagulation optimization and clinical impact of post-transplant deep vein thrombosis: clinical impact and a VV-ECMO subgroup analysis.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Impact of pre-transplant veno-venous extracorporeal membrane oxygenation on post-lung transplant infections.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Article

133 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jenelle BadulakFrom the Department of Emergency Medicine, University of Washington, Seattle, Washington.ORCID 0000-0001-9024-1075
M Velia AntoniniGeneral ICU, University Hospital of Parma, Parma, Italy.ORCID 0000-0003-4276-3404
Christine M SteadExtracorporeal Life Support Organization.
Lara ShekerdemianTexas Children's Hospital, Baylor College of Medicine, Houston, Texas.ORCID 0000-0002-6608-9832
Lakshmi RamanChildren's Medical Center of Dallas, University of Texas Southwestern Medical Center, Dallas, Texas.
Matthew L PadenEmory University, Children's Healthcare of Atlanta, Atlanta, Georgia.
Cara AgerstrandDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
Robert H BartlettUniversity of Michigan, Ann Arbor, Michigan.
Nicholas BarrettDepartment of Critical Care, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.ORCID 0000-0002-4641-8192
Alain CombesInstitute of Cardiometabolism and Nutrition, INSERM, Sorbonne Université, Paris, France.
Roberto LorussoDepartment of Cardio-Thoracic Surgery, Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.ORCID 0000-0002-1777-2045
Thomas MuellerDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Mark T OginoNemours Children's Health System, Wilmington, Delaware.ORCID 0000-0002-3580-4637
Giles PeekCongenital Heart Center, Departments of Surgery and Pediatrics, University of Florida, Gainesville, Florida.ORCID 0000-0002-1313-6498
Vincent PellegrinoIntensive Care Unit, Alfred Health Melbourne, Victoria, Australia.ORCID 0000-0002-0438-1977
Ahmed A RabieCritical Care ECMO Service, King Saud Medical City, Ministry Of Health (MOH), Riyadh, Saudi Arabia.ORCID 0000-0002-0438-1977
Leonardo SalazarFundación Cardiovascular de Colombia, Floridablanca, Santander, Colombia.
Matthieu SchmidtService de Médecine Intensive-Réanimation, Institut de Cardiologie, AP-HP, Sorbonne Université Hôpital Pitié-Salpêtrière, Paris, France.
Kiran ShekarAdult Intensive Care Services, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Graeme MacLarenNational University Hospital, Singapore.ORCID 0000-0002-1307-4274
Daniel BrodieDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.ORCID 0000-0002-0813-3145
ELSO COVID-19 Working Group Members

Funding

Physician Postdoctoral Research Training in Perioperative Medicine (PPRTPM)T32GM112596 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Roderic G Eckenhoff, Max Kelz · 2015 to 2026
$3.4M
NIGMS NIH HHS T32 GM112596
6 · The paper itself

Abstract

disclaimerThis is an updated guideline from the Extracorporeal Life Support Organization (ELSO) for the role of extracorporeal membrane oxygenation (ECMO) for patients with severe cardiopulmonary failure due to coronavirus disease 2019 (COVID-19). The great majority of COVID-19 patients (>90%) requiring ECMO have been supported using venovenous (V-V) ECMO for acute respiratory distress syndrome (ARDS). While COVID-19 ECMO run duration may be longer than in non-COVID-19 ECMO patients, published mortality appears to be similar between the two groups. However, data collection is ongoing, and there is a signal that overall mortality may be increasing. Conventional selection criteria for COVID-19-related ECMO should be used; however, when resources become more constrained during a pandemic, more stringent contraindications should be implemented. Formation of regional ECMO referral networks may facilitate communication, resource sharing, expedited patient referral, and mobile ECMO retrieval. There are no data to suggest deviation from conventional ECMO device or patient management when applying ECMO for COVID-19 patients. Rarely, children may require ECMO support for COVID-19-related ARDS, myocarditis, or multisystem inflammatory syndrome in children (MIS-C); conventional selection criteria and management practices should be the standard. We strongly encourage participation in data submission to investigate the optimal use of ECMO for COVID-19.

Indexed as

Extracorporeal Membrane OxygenationPractice Guidelines as TopicSARS-CoV-2COVID-19HumansRespiratory Distress Syndrome

Identifiers

PMID33657573
PMCPMC8078022

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.